TY - JOUR
T1 - Dose-dependent effects of recombinant human interleukin-11 on the systemic hemodynamic function and urination
AU - Honma, Kaneatsu
AU - Koles, Nancy L.
AU - Alam, Hasan B.
AU - Keith, James C.
AU - Pollack, Matthew
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - The purpose of this study was to determine whether recombinant human interleukin-11 (rhIL-11) could dose-dependently improve the hemodynamic function. Using a swine hemorrhagic shock model, rhIL-11 was given at the beginning of resuscitation. The animals were randomized to receive a single dose of rhIL-11 (5, 20, or 50 μg/kg, group I to III for respectively) or saline (group IV). Blood, urine and both pleural and peritoneal effusion were thus obtained and analyzed. The mean arterial pressure (MAP) was higher post-resuscitation (PR) in group III (62.9±8.2 mmHg) than in groups I, II and IV (54.9±1.7, 53.9±4.3, 55.9±9.4 mmHg, respectively) (P<0.01). The urine output (I: 999±428, II: 1249±180, III: 1434±325, IV: 958±390 ml) and the cardiac output (CO) (I: 3.01±0.66, II: 3.30±0.49, III: 3.43±0.57, IV: 2.73±0.49 L/min.) increased in a dose dependent manner of rhIL-11. CO level and urine output were significantly higher in group III than in group IV (P<0.05). In addition, the volume of third space fluid loss (pleural and peritoneal effusion) of group III was significantly lower than other groups (I: 157±32, II: 138±32, III: 82±21, IV: 125±32 ml) (P<0.05). In conclusion, even a low dose of rhIL-11 improved the hemodynamic functions dose-dependently in a porcine model of hemorrhagic shock, although the relationship did not demonstrate a simple linearity.
AB - The purpose of this study was to determine whether recombinant human interleukin-11 (rhIL-11) could dose-dependently improve the hemodynamic function. Using a swine hemorrhagic shock model, rhIL-11 was given at the beginning of resuscitation. The animals were randomized to receive a single dose of rhIL-11 (5, 20, or 50 μg/kg, group I to III for respectively) or saline (group IV). Blood, urine and both pleural and peritoneal effusion were thus obtained and analyzed. The mean arterial pressure (MAP) was higher post-resuscitation (PR) in group III (62.9±8.2 mmHg) than in groups I, II and IV (54.9±1.7, 53.9±4.3, 55.9±9.4 mmHg, respectively) (P<0.01). The urine output (I: 999±428, II: 1249±180, III: 1434±325, IV: 958±390 ml) and the cardiac output (CO) (I: 3.01±0.66, II: 3.30±0.49, III: 3.43±0.57, IV: 2.73±0.49 L/min.) increased in a dose dependent manner of rhIL-11. CO level and urine output were significantly higher in group III than in group IV (P<0.05). In addition, the volume of third space fluid loss (pleural and peritoneal effusion) of group III was significantly lower than other groups (I: 157±32, II: 138±32, III: 82±21, IV: 125±32 ml) (P<0.05). In conclusion, even a low dose of rhIL-11 improved the hemodynamic functions dose-dependently in a porcine model of hemorrhagic shock, although the relationship did not demonstrate a simple linearity.
KW - Dose-dependent
KW - Effusion
KW - Hemorrhagic shock
KW - Recombinant human interleukin-11
KW - Urination
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U2 - 10.2739/kurumemedj.54.73
DO - 10.2739/kurumemedj.54.73
M3 - Article
C2 - 18475040
AN - SCOPUS:44649098999
SN - 0023-5679
VL - 54
SP - 73
EP - 76
JO - Kurume Medical Journal
JF - Kurume Medical Journal
IS - 3-4
ER -