Dose-dependent effects of recombinant human interleukin-11 on the systemic hemodynamic function and urination

The purpose of this study was to determine whether recombinant human interleukin-11 (rhIL-11) could dose-dependently improve the hemodynamic function. Using a swine hemorrhagic shock model, rhIL-11 was given at the beginning of resuscitation. The animals were randomized to receive a single dose of rhIL-11 (5, 20, or 50 μg/kg, group I to III for respectively) or saline (group IV). Blood, urine and both pleural and peritoneal effusion were thus obtained and analyzed. The mean arterial pressure (MAP) was higher post-resuscitation (PR) in group III (62.9±8.2 mmHg) than in groups I, II and IV (54.9±1.7, 53.9±4.3, 55.9±9.4 mmHg, respectively) (P<0.01). The urine output (I: 999±428, II: 1249±180, III: 1434±325, IV: 958±390 ml) and the cardiac output (CO) (I: 3.01±0.66, II: 3.30±0.49, III: 3.43±0.57, IV: 2.73±0.49 L/min.) increased in a dose dependent manner of rhIL-11. CO level and urine output were significantly higher in group III than in group IV (P<0.05). In addition, the volume of third space fluid loss (pleural and peritoneal effusion) of group III was significantly lower than other groups (I: 157±32, II: 138±32, III: 82±21, IV: 125±32 ml) (P<0.05). In conclusion, even a low dose of rhIL-11 improved the hemodynamic functions dose-dependently in a porcine model of hemorrhagic shock, although the relationship did not demonstrate a simple linearity.