Dosimetry robustness with stochastic optimization

Omid Nohadani*, Joao Seco, Benjamin C. Martin, Thomas Bortfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


All radiation therapy treatment planning relies on accurate dose calculation. Uncertainties in dosimetric prediction can significantly degrade an otherwise optimal plan. In this work, we introduce a robust optimization method which handles dosimetric errors and warrants for high-quality IMRT plans. Unlike other dose error estimations, we do not rely on the detailed knowledge about the sources of the uncertainty and use a generic error model based on random perturbation. This generality is sought in order to cope with a large variety of error sources. We demonstrate the method on a clinical case of lung cancer and show that our method provides plans that are more robust against dosimetric errors and are clinically acceptable. In fact, the robust plan exhibits a two-fold improved equivalent uniform dose compared to the non-robust but optimized plan. The achieved speedup will allow computationally extensive multi-criteria or beam-angle optimization approaches to warrant for dosimetrically relevant plans.

Original languageEnglish (US)
Pages (from-to)3421-3432
Number of pages12
JournalPhysics in Medicine and Biology
Issue number11
StatePublished - 2009

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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