Doxacurium and mivacurium do not trigger malignant hyperthermia in susceptible swine

R. L. Sufit, J. F. Kreul*, Y. M. Bellay, P. Helmer, D. B. Brunson, J. Will

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The role of succinylcholine in the precipitation of malignant hyperthermia (MH) necessitates the testing of new neuromuscular relaxants for their ability to trigger MH in MH-susceptible swine before general human use. We tested doxacurium and mivacurium, two new nondepolarizing bis-benzylisoquinolinium neuromuscular relaxants, at ED95 and at four times ED95 doses in swine previously documented to be MH-susceptible. In one of the 16 animals was MH triggered after administration of these relaxants, whereas all animals developed fatal MH after administration of halothane or halothane plus succinylcholine. Muscle biopsy specimens taken before administration of the relaxant confirmed that all animals had increased sensitivity to halothane, caffeine, or both. Thus, we conclude that doxacurium and mivacurium are not triggering agents of malignant hyperthermia in MH-susceptible swine.

Original languageEnglish (US)
Pages (from-to)285-287
Number of pages3
JournalAnesthesia and analgesia
Volume71
Issue number3
DOIs
StatePublished - 1990

Keywords

  • Anesthetics, volatile-halothane
  • Hyperthermia, malignant
  • Neuromuscular relaxants, doxacurium, mivacurium

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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