Doxycycline or Oral Corticosteroids for Nasal Polyps

Leslie C. Grammer*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The study by Van Zele etal reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps. The primary end point was reduction in nasal polyp score which was graded 0 to 4 on each side, resulting in a score range of 0 to 8; the score was determined at baseline and weeks 1, 2, 4, 8, and 12. Entry criteria required that the patient either have recurrent polyps after surgery or massive polyps (grade 3 or 4); the total polyp score in each of the 3 groups averaged approximately 6. The patient population in this study was therefore at the severe end of the spectrum; results may not be generalizable to patients with milder disease.

Original languageEnglish (US)
Pages (from-to)541-542
Number of pages2
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume1
Issue number5
DOIs
StatePublished - Sep 1 2013

Keywords

  • Doxycycline
  • ECP
  • Methyl prednisolone
  • Polyps

ASJC Scopus subject areas

  • Immunology and Allergy

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