Abstract
The study by Van Zele etal reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps. The primary end point was reduction in nasal polyp score which was graded 0 to 4 on each side, resulting in a score range of 0 to 8; the score was determined at baseline and weeks 1, 2, 4, 8, and 12. Entry criteria required that the patient either have recurrent polyps after surgery or massive polyps (grade 3 or 4); the total polyp score in each of the 3 groups averaged approximately 6. The patient population in this study was therefore at the severe end of the spectrum; results may not be generalizable to patients with milder disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-542 |
| Number of pages | 2 |
| Journal | Journal of Allergy and Clinical Immunology: In Practice |
| Volume | 1 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2013 |
Funding
This work is supported by the Ernest S Bazley Trust to Northwestern University and Northwestern Memorial Hospital . Conflicts of interest: L. C. Grammer has received research and travel support from the National Institutes of Health, Food Allergy Network, and S&C Electric ; has received the Bazley Foundation Grant; has received consultancy fees from Astellas Pharmaceuticals ; is employed by Northwestern University and the Northwestern Medical Faculty Foundation; has received lecture fees from the AAAAI and Beth Israel Hospital; and receives royalties from Lippincott, UpToDate, BMJ, and Elsevier.
Keywords
- Doxycycline
- ECP
- Methyl prednisolone
- Polyps
ASJC Scopus subject areas
- Immunology and Allergy