Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

Agnes E. Thorarinsdottir; T. David Harris

doi:10.1039/C8CC09520E

Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

Agnes E. Thorarinsdottir, T. David Harris^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit⁻¹ at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.

Original language	English (US)
Pages (from-to)	794-797
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	6
DOIs	https://doi.org/10.1039/C8CC09520E
State	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe",

abstract = "The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit−1 at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.",

author = "Thorarinsdottir, {Agnes E.} and Harris, {T. David}",

note = "Funding Information: This research was funded by Northwestern University. A. E. T. acknowledges the Leifur Eiriksson Foundation for funding support. We thank Prof. T. J. Meade for use of his HPLC system and lyophilizer, and Dr. D. Z. Zee for helpful discussions. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/C8CC09520E",

language = "English (US)",

volume = "55",

pages = "794--797",

journal = "Chemical Communications",

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TY - JOUR

T1 - Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

AU - Thorarinsdottir, Agnes E.

AU - Harris, T. David

N1 - Funding Information: This research was funded by Northwestern University. A. E. T. acknowledges the Leifur Eiriksson Foundation for funding support. We thank Prof. T. J. Meade for use of his HPLC system and lyophilizer, and Dr. D. Z. Zee for helpful discussions. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit−1 at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.

AB - The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit−1 at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.

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UR - http://www.scopus.com/inward/citedby.url?scp=85059972005&partnerID=8YFLogxK

U2 - 10.1039/C8CC09520E

DO - 10.1039/C8CC09520E

M3 - Article

C2 - 30569919

AN - SCOPUS:85059972005

SN - 1359-7345

VL - 55

SP - 794

EP - 797

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe

Abstract

ASJC Scopus subject areas

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