Driving proteins off DNA using applied tension

John F. Marko*, Eric D. Siggia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Proteins that bind DNA so as to reduce its end-to-end length can be dissociated by application of force. The thermodynamics of this process are discussed, with special attention to the case of histories bound to DNA (i.e., a string of nucleosomes, or chromatin fiber). The histone octamer is predicted to be driven off chromatin fiber for tensions >2 piconewtons.

Original languageEnglish (US)
Pages (from-to)2173-2178
Number of pages6
JournalBiophysical Journal
Issue number4
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Biophysics


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