Drosophila clock can generate ectopic circadian clocks

Jie Zhao, Valerie L. Kilman, Kevin P. Keegan, Ying Peng, Patrick Emery, Michael Rosbash, Ravi Allada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Circadian rhythms of behavior, physiology, and gene expression are present in diverse tissues and organisms. The function of the transcriptional activator, Clock, is necessary in both Drosophila and mammals for the expression of many core clock components. We demonstrate in Drosophila that Clock misexpression in naïve brain regions induces circadian gene expression. This includes major components of the pacemaker program, as Clock also activates the rhythmic expression of cryptochrome, a gene that CLOCK normally represses. Moreover, this ectopic clock expression has potent effects on behavior, radically altering locomotor activity patterns. We propose that Clock is uniquely able to induce and organize the core elements of interdependent feedback loops necessary for circadian rhythms.

Original languageEnglish (US)
Pages (from-to)755-766
Number of pages12
Issue number6
StatePublished - Jun 13 2003

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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