Drug discovery in renal disease - Towards a more efficient framework

Toshio Miyata*, Tsuyoshi Ando, Hisami Hiragi, Kanako Watanabe, Fumi Yamamoto, Douglas E Vaughan, Tatsuo Kurokawa, Yoshiteru Oshima, Charles Van Ypersele De Strihou, Masahiro Takeuchi

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

The time and cost involved in bringing new drugs to the market hamper their approval. This problem is especially apparent in the case of renal diseases. Efficient drug research requires an a priori understanding of disease pathophysiology, target validation, rational and efficient drug discovery strategies and early testing of the physiological and pharmacological effects of the new agent in humans. Drug development initiated by academia benefits from international research networks and relies on internationally acceptable high-quality nonclinical data packages and bulk investigational drugs. Academics should, therefore, better understand pharmaceutical practice regulations and novel, efficient drug-development strategies. Many researchers remain unfamiliar with these areas and should collaborate with regulatory authorities to discover and validate surrogate markers for use in drug development, and to efficiently and effectively maximize the benefits and minimize the adverse effects of new drugs. The Japanese government and regulatory authorities have implemented a framework to encourage such collaborations; extension of this framework beyond its current reach is envisaged.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalNature Reviews Nephrology
Volume10
Issue number5
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Nephrology

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    Miyata, T., Ando, T., Hiragi, H., Watanabe, K., Yamamoto, F., Vaughan, D. E., Kurokawa, T., Oshima, Y., Van Ypersele De Strihou, C., & Takeuchi, M. (2014). Drug discovery in renal disease - Towards a more efficient framework. Nature Reviews Nephrology, 10(5), 290-296. https://doi.org/10.1038/nrneph201436