Drug-induced hypersensitivity syndrome with myocardial involvement treated with tofacitinib

William E. Damsky, Matthew D. Vesely, Alfred Ian Lee, Jaehyuk Choi, Ana Claire Meyer, Michael Chen, Tariq Ahmad, Brett King*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations
Original languageEnglish (US)
Pages (from-to)1018-1026
Number of pages9
JournalJAAD Case Reports
Volume5
Issue number12
DOIs
StatePublished - Dec 2019

Funding

Conflicts of Interest: Dr Damsky has research funding from Pfizer and is a consultant for Eli Lilly. Dr Vesely's spouse works at Regeneron. Dr Choi has served on advisory boards for Merck, Pfizer, and EMD Serono. This article was prepared while Dr Meyer was employed by Yale University. The opinions expressed in this article are Dr Meyer's own and do not reflect the views of the US Army Medical Research and Material Command, the Department of the Army, the Department of Defense, or the United States Government. Dr King an investigator for Concert Pharmaceuticals Inc, Eli Lilly and Company, and Pfizer Inc and is a consultant to and/or has served on advisory boards for Aclaris Therapeutics, Arena Pharmaceuticals, Concert Pharmaceuticals Inc, Dermavant Sciences, Eli Lilly and Company, and Pfizer Inc; he is on speakers bureaus for Pfizer Inc, Regeneron, and Sanofi Genzyme. The rest of the authors have no conflicts to disclose. Funding sources: Supported by a gift (to Dr King) from the Ranjini and Ajay Poddar Resource Fund for Dermatologic Diseases Research. Dr Damsky is supported by the Dermatology Foundation. Dr Meyer was supported by the Fogarty International Center/National Institutes of Health (K01TW008764-02). Conflicts of Interest: Dr Damsky has research funding from Pfizer and is a consultant for Eli Lilly. Dr Vesely's spouse works at Regeneron. Dr Choi has served on advisory boards for Merck, Pfizer, and EMD Serono. This article was prepared while Dr Meyer was employed by Yale University. The opinions expressed in this article are Dr Meyer's own and do not reflect the views of the US Army Medical Research and Material Command, the Department of the Army, the Department of Defense, or the United States Government. Dr King an investigator for Concert Pharmaceuticals Inc, Eli Lilly and Company, and Pfizer Inc and is a consultant to and/or has served on advisory boards for Aclaris Therapeutics, Arena Pharmaceuticals, Concert Pharmaceuticals Inc, Dermavant Sciences, Eli Lilly and Company, and Pfizer Inc; he is on speakers bureaus for Pfizer Inc, Regeneron, and Sanofi Genzyme. The rest of the authors have no conflicts to disclose. Funding sources: Supported by a gift (to Dr King) from the Ranjini and Ajay Poddar Resource Fund for Dermatologic Diseases Research. Dr Damsky is supported by the Dermatology Foundation . Dr Meyer was supported by the Fogarty International Center / National Institutes of Health ( K01TW008764-02 ).

Keywords

  • DIHS
  • DRESS
  • JAK inhibitor
  • Janus kinase
  • acute necrotizing eosinophilic myocarditits
  • drug reaction with eosinophilia and systemic symptoms
  • drug-induced hypersensitivity syndrome
  • tofacitinib

ASJC Scopus subject areas

  • Dermatology

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