TY - JOUR
T1 - Drug Ingestion During Pregnancy
T2 - Infrequent Exposure in a Contemporary United States Sample
AU - Simpson, Joe Leigh
AU - Morey, Arthur
AU - Metzger, Boyd E.
AU - Brown, Zane
AU - Van Allen, Margot
AU - Elias, Sherman
AU - Mills, James L.
AU - Aarons, Jerome H.
AU - Knopp, Robert H.
AU - Holmes, Lewis B.
AU - Jovanovic-Peterson, Lois
PY - 1989/4
Y1 - 1989/4
N2 - Drug ingestion in a cohort of United States women proved consistently lower than in prior United States populations. Participating were 342 insulin-dependent diabetic and 387 control subjects who were enrolled before conception (76%) or no later than 21 days after conception (24%). Drug exposures were then recorded at entry and periodically throughout organogenesis (gestational weeks 6, 8,10). During gestational weeks 1 to 10, approximately two thirds of the subjects were exposed to no agent other than oral iron, oral vitamins, or insulin (diabetic subjects). The mean exposures in gestational weeks 1 to 10 were 0.72 ± 1.05 (SD) for diabetic women and 0.54 ± 0.96 for control subjects; throughout pregnancy, the mean exposures were 1.26 ± 1.66 and 1.58 ± 1.78, respectively. The low exposure frequency in this contemporary United States population is highly encouraging. However, it follows that collaborative cohort efforts may be necessary in order to assess teratogenicity of drugs because relatively few women are now exposed.
AB - Drug ingestion in a cohort of United States women proved consistently lower than in prior United States populations. Participating were 342 insulin-dependent diabetic and 387 control subjects who were enrolled before conception (76%) or no later than 21 days after conception (24%). Drug exposures were then recorded at entry and periodically throughout organogenesis (gestational weeks 6, 8,10). During gestational weeks 1 to 10, approximately two thirds of the subjects were exposed to no agent other than oral iron, oral vitamins, or insulin (diabetic subjects). The mean exposures in gestational weeks 1 to 10 were 0.72 ± 1.05 (SD) for diabetic women and 0.54 ± 0.96 for control subjects; throughout pregnancy, the mean exposures were 1.26 ± 1.66 and 1.58 ± 1.78, respectively. The low exposure frequency in this contemporary United States population is highly encouraging. However, it follows that collaborative cohort efforts may be necessary in order to assess teratogenicity of drugs because relatively few women are now exposed.
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U2 - 10.1055/s-2007-999586
DO - 10.1055/s-2007-999586
M3 - Article
C2 - 2712923
AN - SCOPUS:0024510634
SN - 0735-1631
VL - 6
SP - 244
EP - 251
JO - American journal of perinatology
JF - American journal of perinatology
IS - 2
ER -