Abstract
Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 483-489 |
| Number of pages | 7 |
| Journal | Biomacromolecules |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 13 2017 |
Funding
Research reported in this publication was supported by the Center for Cancer Nanotechnology Excellence initiative of the National Cancer Institute of the National Institutes of Health under Award Nos. U54CA151880 and U54CA199091. This material is also based upon work supported by the AFOSR under Award No. FA9550-12-1-0280. C.A.M. additionally acknowledges support from the NTU-NU Institute for NanoMedicine located at the International Institute for Nanotechnology, Northwestern University and the Nanyang Technological University, Singapore. Instruments in the Northwestern University IMSERC, Keck Biophysics, and EPIC/NUANCE facilities were purchased with grants from NSF-NSEC (NSF EEC-0647560), NIH−CCNE, NSF-MRSEC (NSF DMR-1121262), the Keck Foundation, the State of Illinois, and Northwestern University. We additionally thank the reviewers of the initial version of this manuscript for comments that help improving its quality. The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the AFOSR.
ASJC Scopus subject areas
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
