Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

Resham J. Banga, Sai Archana Krovi, Suguna P. Narayan, Anthony J. Sprangers, Guoliang Liu, Chad A. Mirkin, Son Binh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalBiomacromolecules
Volume18
Issue number2
DOIs
StatePublished - Feb 13 2017

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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