Drug release from hydrazone-containing peptide amphiphiles

John B. Matson, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticle

93 Scopus citations


Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Original languageEnglish (US)
Pages (from-to)7962-7964
Number of pages3
JournalChemical Communications
Issue number28
StatePublished - Jul 28 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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