Dscam mutation leads to hydrocephalus and decreased motor function

Yiliang Xu, Haihong Ye*, Yan Shen, Qi Xu, Li Zhu, Jianghong Liu, Jane Y. Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching, dendritic tiling and cell spacing. However, the function of the mammalian DSCAM gene in the formation of the nervous system remains unclear. Here, we show that Dscamdel17 mutant mice exhibit severe hydrocephalus, decreased motor function and impaired motor learning ability. Our data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system.

Original languageEnglish (US)
Pages (from-to)647-655
Number of pages9
JournalProtein and Cell
Volume2
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • Down syndrome cell adhesion molecule
  • hydrocephalus
  • motor function
  • motor learning

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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