DU-PAN-2 levels in serum and pancreatic ductal fluids of patients with benign and malignant pancreatic disease

David M. Mahvi, H. F. Seigler, William C. Meyers, Holger Kalthoff, Wolff H. Schmiegel, Richard S. Metzgar*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Previous studies have shown that the DU-PAN-2 antigen is elevated in, 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (<400 U/ml) in 99% of normal subjects. In this study, the DU-PAN-2 antigen level of the serum and pancreatic ductal fluid in patients with malignant pancreatic disease were compared to antigen levels in patients with benign pancreatic diseases. Six percent of patients with chronic pancreatitis and 13% of patients with severe acute pancreatitis had elevated DU-PAN-2 antigen levels in their sera. Pancreatic ductal fluid DU-PAN-2 levels were elevated in 33% (11 of 33) of patients with pancreatic adenocarcinomas, whereas 16% (5 of 31) of patients with chronic pancreatitis and 38% (8 of 21) of control patients had elevated secretion levels. Unlike DU-PAN-2, the tumor markers carcinoembryonic antigen (CEA) and carcinoma (CA) 19-9 were elevated in 90 and 100%, respectively, of secretions of patients with pancreatic adenocarcinoma. However, CEA and CA 19-9 ductal fluid levels were also elevated in patients with chronic pancreatitis (CEA: 61%; CA 19-9: 85%), and therefore these markers are not helpful in distinguishing benign from malignant pancreatic disease. The physiologic implications of elevated DU-PAN-2 serum antigen levels in patients with normal ductal fluid DU-PAN-2 levels are discussed.

Original languageEnglish (US)
Pages (from-to)488-493
Number of pages6
JournalPancreas
Volume3
Issue number4
DOIs
StatePublished - Aug 1988

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Keywords

  • DU-PAN-2 antigen
  • Pancreatic adenocarcinoma
  • Pancreatic ductal fluid
  • Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Mahvi, D. M., Seigler, H. F., Meyers, W. C., Kalthoff, H., Schmiegel, W. H., & Metzgar, R. S. (1988). DU-PAN-2 levels in serum and pancreatic ductal fluids of patients with benign and malignant pancreatic disease. Pancreas, 3(4), 488-493. https://doi.org/10.1097/00006676-198808000-00020