Dual contrast magnetic resonance imaging tracking of iron-labeled cells in vivo

Shengyong Wu, Longjiang Zhang, Jianhui Zhong, Zhuoli Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Negative-contrast magnetic resonance imaging (MRI) methods utilizing magnetic susceptibility contrast agents have become one of the most widely used approaches in cellular imaging research. However, visualizing and tracking super-paramagnetic iron oxide nanoparticle (SPIO)-labeled cells on the basis of negative-contrast can limit specificity and sensitivity. Therefore, there has been a strong motivation to explore MRI methods for cellular imaging with either positive or dual contrast (both positive and negative) for identifying labeled cells; these methods offer the potential to improve significantly the sensitivity and specificity of MRI-based cell-tracking approaches. In this review, current state-of-the-art positive- and dual-contrast MRI techniques and contrast agents are described specifically for applications involving in vivo cellular tracking and imaging.

Original languageEnglish (US)
Pages (from-to)859-869
Number of pages11
Issue number7
StatePublished - Nov 2010


  • cell tracking
  • dual-contrast imaging
  • magnetic resonance imaging
  • superparamagnetic iron oxide nanoparticle

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Cancer Research
  • Transplantation


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