Dual-controlled nanoparticles exhibiting and logic

Sarah Angelos, Ying Wei Yang, Niveen M. Khashab, J. Fraser Stoddart, Jeffrey I. Zink

Research output: Contribution to journalArticlepeer-review

285 Scopus citations


(Figure Presented) Dual-controlled nanoparticles (DCNPs) are synthesized by attaching two different types of molecular machines, light-responsive nanoimpellers and pH-responsive nanovalves, to different regions of mesoporous silica nanoparticles. Nanoimpellers are based on azobenzene derivatives that are tethered to the nanopore interiors, while nanovalves are based on [2] pseudorotaxanes that are tethered to the nanoparticle surfaces. The different molecular machines operate through separate mechanisms to control the release of guest molecules that are loaded into the nanopores. When used in conjunction with one another, a sophisticated controllable release system behaving as an AND logic gate is obtained.

Original languageEnglish (US)
Pages (from-to)11344-11346
Number of pages3
JournalJournal of the American Chemical Society
Issue number32
StatePublished - Aug 19 2009

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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