Dual function of Sox1 in telencephalic progenitor cells

Lixin Kan*, Ali Jalali, Li Ru Zhao, Xiaojing Zhou, Tammy McGuire, Ilias Kazanis, Vasso Episkopou, Alexander G. Bassuk, John A. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The transcription factor, Sox1 has been implicated in the maintenance of neural progenitor cell status, but accumulating evidence suggests that this is only part of its function. This study examined the role of Sox1 expression in proliferation, lineage commitment, and differentiation by telencephalic neural progenitor cells in vitro and in vivo, and further clarified the pattern of Sox1 expression in postnatal and adult mouse brain. Telencephalic neural progenitor cells isolated from Sox1 null embryos formed neurospheres normally, but were specifically deficient in neuronal differentiation. Conversely, overexpression of Sox1 in the embryonic telencephalon in vivo both expanded the progenitor pool and biased neural progenitor cells towards neuronal lineage commitment. Sox1 mRNA and protein were found to be persistently expressed in the postnatal and adult brain in both differentiated and neurogenic regions. Importantly, in differentiated regions Sox1 co-labeled only with neuronal markers. These observations, coupled with previous studies, suggest that Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment.

Original languageEnglish (US)
Pages (from-to)85-98
Number of pages14
JournalDevelopmental Biology
Volume310
Issue number1
DOIs
StatePublished - Oct 1 2007

Keywords

  • Differentiation
  • Neural progenitor cells
  • Neural stem cells
  • Neurogenesis
  • Sox1

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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