Dual radiopharmaceutical imaging in congenital asplenia syndrome.

B. K. Rao*, R. M. Shore, L. M. Lieberman, R. E. Polcyn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Asplenia was suspected in one patient with combined immunodeficiency syndrome and 5 with congenital cardiac anomalies who had Howell-Jolly bodies on peripheral blood smears. 99mTc-sulfur colloid scans were equivocal for absence of the spleen. When they were compared with the 99mTc-PIPIDA hepatobiliary images, a discrepancy in organ morphology between the two scans indicated that the spleen was present, whereas similarity of the two images suggested asplenia. This procedure was useful in establishing asplenia in 4 patients and confirming the presence of a rudimentary or ectopic spleen in 2 others. Unequivocal demonstration of the spleen on the sulfur colloid scans makes the hepatobiliary study unnecessary, while unequivocal demonstration of a normal-appearing liver without splenic activity may warrant a tagged red-cell study for a more complete evaluation.

Original languageEnglish (US)
Pages (from-to)805-810
Number of pages6
Issue number3
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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