Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

Kevin B. Daniel, Cassandra E. Callmann, Nathan C. Gianneschi*, Seth M. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

Original languageEnglish (US)
Pages (from-to)2126-2128
Number of pages3
JournalChemical Communications
Volume52
Issue number10
DOIs
StatePublished - 2016

Funding

We thank the UC San Diego Molecular Mass Spectrometry Facility (MMSF) for assistance with experiments. This work was supported by a grant from the National Institutes of Health, National Institute of General Medical Sciences (R01 GM098435; K. B. D., S.M. C.), as well as the National Institute for Biomedical Imaging and Biomedical Engineering (R01 EB011633; C. E. C., N. C. G.). In addition, we thank the Army Research Office (ARO) for their support for this work (W911NF-14-1-0169). C. E. C. thanks the Cancer Researchers in Nanotechnology Program at UC San Diego for fellowship support.

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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