Abstract
Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2126-2128 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2016 |
Funding
We thank the UC San Diego Molecular Mass Spectrometry Facility (MMSF) for assistance with experiments. This work was supported by a grant from the National Institutes of Health, National Institute of General Medical Sciences (R01 GM098435; K. B. D., S.M. C.), as well as the National Institute for Biomedical Imaging and Biomedical Engineering (R01 EB011633; C. E. C., N. C. G.). In addition, we thank the Army Research Office (ARO) for their support for this work (W911NF-14-1-0169). C. E. C. thanks the Cancer Researchers in Nanotechnology Program at UC San Diego for fellowship support.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- General Chemistry
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Catalysis