@article{00cfb558b7dc404981210871e16ee7a5,
title = "Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species",
abstract = "Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.",
author = "Daniel, {Kevin B.} and Callmann, {Cassandra E.} and Gianneschi, {Nathan C.} and Cohen, {Seth M.}",
note = "Funding Information: We thank the UC San Diego Molecular Mass Spectrometry Facility (MMSF) for assistance with experiments. This work was supported by a grant from the National Institutes of Health, National Institute of General Medical Sciences (R01 GM098435; K. B. D., S.M. C.), as well as the National Institute for Biomedical Imaging and Biomedical Engineering (R01 EB011633; C. E. C., N. C. G.). In addition, we thank the Army Research Office (ARO) for their support for this work (W911NF-14-1-0169). C. E. C. thanks the Cancer Researchers in Nanotechnology Program at UC San Diego for fellowship support. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",
year = "2016",
doi = "10.1039/c5cc09164k",
language = "English (US)",
volume = "52",
pages = "2126--2128",
journal = "Chemical Communications",
issn = "1359-7345",
number = "10",
}