Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

Kevin B. Daniel, Cassandra E. Callmann, Nathan C. Gianneschi*, Seth M. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

Original languageEnglish (US)
Pages (from-to)2126-2128
Number of pages3
JournalChemical Communications
Volume52
Issue number10
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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