Durability of benefits from supervised treadmill exercise in people with peripheral artery disease

Mary M. McDermott*, Melina R. Kibbe, Jack M. Guralnik, Luigi Ferrucci, Michael H. Criqui, Kathryn Domanchuk, Lu Tian, Lihui Zhao, Lingyu Li, Kruti Patel, Tamar S. Polonsky

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background-—It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6-minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results-—A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6-minute walk distance and short physical performance battery at 6-month follow-up and have been reported previously. Secondary outcomes were change in 6-minute walk and short physical performance battery at 12-month follow-up and are reported here. A group of 134 participants (86%) completed the 12-month follow-up. At 6-month follow-up, compared with control, 6-minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9-58.3, P=0.001). Between 6-and 12-month follow-up, 6-minute walk distance significantly declined ( 28.6 m, 95% CI= 52.6 to 4.5, P=0.020) and physical activity declined 272 activity units (95% CI= 546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12-month follow-up, 6 months after completing supervised treadmill exercise, change in 6-minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI= 17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6-month or 12-month follow-up. Conclusions-—A 6-month supervised treadmill exercise intervention that improved 6-minute walk distance at 6-month follow-up did not have persistent benefit at 12-month follow-up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease.

Original languageEnglish (US)
Article numbere009380
JournalJournal of the American Heart Association
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Peripheral Arterial Disease
Control Groups
Resistance Training
Telephone

Keywords

  • Exercise
  • Exercise training
  • Functional capacity impairment
  • Peripheral artery disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

McDermott, Mary M. ; Kibbe, Melina R. ; Guralnik, Jack M. ; Ferrucci, Luigi ; Criqui, Michael H. ; Domanchuk, Kathryn ; Tian, Lu ; Zhao, Lihui ; Li, Lingyu ; Patel, Kruti ; Polonsky, Tamar S. / Durability of benefits from supervised treadmill exercise in people with peripheral artery disease. In: Journal of the American Heart Association. 2019 ; Vol. 8, No. 1.
@article{4128ec42100f4360ba8c189e42d9e22a,
title = "Durability of benefits from supervised treadmill exercise in people with peripheral artery disease",
abstract = "Background-—It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6-minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results-—A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6-minute walk distance and short physical performance battery at 6-month follow-up and have been reported previously. Secondary outcomes were change in 6-minute walk and short physical performance battery at 12-month follow-up and are reported here. A group of 134 participants (86{\%}) completed the 12-month follow-up. At 6-month follow-up, compared with control, 6-minute walk distance improved in the treadmill exercise group (+36.1 m, 95{\%} CI=13.9-58.3, P=0.001). Between 6-and 12-month follow-up, 6-minute walk distance significantly declined ( 28.6 m, 95{\%} CI= 52.6 to 4.5, P=0.020) and physical activity declined 272 activity units (95{\%} CI= 546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12-month follow-up, 6 months after completing supervised treadmill exercise, change in 6-minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95{\%} CI= 17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6-month or 12-month follow-up. Conclusions-—A 6-month supervised treadmill exercise intervention that improved 6-minute walk distance at 6-month follow-up did not have persistent benefit at 12-month follow-up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease.",
keywords = "Exercise, Exercise training, Functional capacity impairment, Peripheral artery disease",
author = "McDermott, {Mary M.} and Kibbe, {Melina R.} and Guralnik, {Jack M.} and Luigi Ferrucci and Criqui, {Michael H.} and Kathryn Domanchuk and Lu Tian and Lihui Zhao and Lingyu Li and Kruti Patel and Polonsky, {Tamar S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1161/JAHA.118.009380",
language = "English (US)",
volume = "8",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "1",

}

McDermott, MM, Kibbe, MR, Guralnik, JM, Ferrucci, L, Criqui, MH, Domanchuk, K, Tian, L, Zhao, L, Li, L, Patel, K & Polonsky, TS 2019, 'Durability of benefits from supervised treadmill exercise in people with peripheral artery disease', Journal of the American Heart Association, vol. 8, no. 1, e009380. https://doi.org/10.1161/JAHA.118.009380

Durability of benefits from supervised treadmill exercise in people with peripheral artery disease. / McDermott, Mary M.; Kibbe, Melina R.; Guralnik, Jack M.; Ferrucci, Luigi; Criqui, Michael H.; Domanchuk, Kathryn; Tian, Lu; Zhao, Lihui; Li, Lingyu; Patel, Kruti; Polonsky, Tamar S.

In: Journal of the American Heart Association, Vol. 8, No. 1, e009380, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Durability of benefits from supervised treadmill exercise in people with peripheral artery disease

AU - McDermott, Mary M.

AU - Kibbe, Melina R.

AU - Guralnik, Jack M.

AU - Ferrucci, Luigi

AU - Criqui, Michael H.

AU - Domanchuk, Kathryn

AU - Tian, Lu

AU - Zhao, Lihui

AU - Li, Lingyu

AU - Patel, Kruti

AU - Polonsky, Tamar S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background-—It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6-minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results-—A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6-minute walk distance and short physical performance battery at 6-month follow-up and have been reported previously. Secondary outcomes were change in 6-minute walk and short physical performance battery at 12-month follow-up and are reported here. A group of 134 participants (86%) completed the 12-month follow-up. At 6-month follow-up, compared with control, 6-minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9-58.3, P=0.001). Between 6-and 12-month follow-up, 6-minute walk distance significantly declined ( 28.6 m, 95% CI= 52.6 to 4.5, P=0.020) and physical activity declined 272 activity units (95% CI= 546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12-month follow-up, 6 months after completing supervised treadmill exercise, change in 6-minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI= 17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6-month or 12-month follow-up. Conclusions-—A 6-month supervised treadmill exercise intervention that improved 6-minute walk distance at 6-month follow-up did not have persistent benefit at 12-month follow-up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease.

AB - Background-—It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6-minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results-—A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6-minute walk distance and short physical performance battery at 6-month follow-up and have been reported previously. Secondary outcomes were change in 6-minute walk and short physical performance battery at 12-month follow-up and are reported here. A group of 134 participants (86%) completed the 12-month follow-up. At 6-month follow-up, compared with control, 6-minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9-58.3, P=0.001). Between 6-and 12-month follow-up, 6-minute walk distance significantly declined ( 28.6 m, 95% CI= 52.6 to 4.5, P=0.020) and physical activity declined 272 activity units (95% CI= 546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12-month follow-up, 6 months after completing supervised treadmill exercise, change in 6-minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI= 17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6-month or 12-month follow-up. Conclusions-—A 6-month supervised treadmill exercise intervention that improved 6-minute walk distance at 6-month follow-up did not have persistent benefit at 12-month follow-up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease.

KW - Exercise

KW - Exercise training

KW - Functional capacity impairment

KW - Peripheral artery disease

UR - http://www.scopus.com/inward/record.url?scp=85059223402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059223402&partnerID=8YFLogxK

U2 - 10.1161/JAHA.118.009380

DO - 10.1161/JAHA.118.009380

M3 - Article

C2 - 30587066

AN - SCOPUS:85059223402

VL - 8

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 1

M1 - e009380

ER -