Durability of benefits from supervised treadmill exercise in people with peripheral artery disease

Mary M. McDermott*, Melina R Kibbe, Jack M. Guralnik, Luigi Ferrucci, Michael H. Criqui, Kathryn Domanchuk, Lu Tian, Lihui Zhao, Lingyu Li, Kruti Patel, Tamar S. Polonsky

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background-—It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6-minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results-—A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6-minute walk distance and short physical performance battery at 6-month follow-up and have been reported previously. Secondary outcomes were change in 6-minute walk and short physical performance battery at 12-month follow-up and are reported here. A group of 134 participants (86%) completed the 12-month follow-up. At 6-month follow-up, compared with control, 6-minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9-58.3, P=0.001). Between 6-and 12-month follow-up, 6-minute walk distance significantly declined ( 28.6 m, 95% CI= 52.6 to 4.5, P=0.020) and physical activity declined 272 activity units (95% CI= 546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12-month follow-up, 6 months after completing supervised treadmill exercise, change in 6-minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI= 17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6-month or 12-month follow-up. Conclusions-—A 6-month supervised treadmill exercise intervention that improved 6-minute walk distance at 6-month follow-up did not have persistent benefit at 12-month follow-up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease.

Original languageEnglish (US)
Article numbere009380
JournalJournal of the American Heart Association
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Exercise
  • Exercise training
  • Functional capacity impairment
  • Peripheral artery disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    McDermott, M. M., Kibbe, M. R., Guralnik, J. M., Ferrucci, L., Criqui, M. H., Domanchuk, K., Tian, L., Zhao, L., Li, L., Patel, K., & Polonsky, T. S. (2019). Durability of benefits from supervised treadmill exercise in people with peripheral artery disease. Journal of the American Heart Association, 8(1), [e009380]. https://doi.org/10.1161/JAHA.118.009380