Duramycin radiosensitization of MCA-RH 7777 hepatoma cells through the elevation of reactive oxygen species

Bowen Yang, Xiaoke Huang, Weiguo Li, Samdeep Mouli, Robert Lewandowski, Andrew Larson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: The objective of this study is to explore the radiosensitization effects of duramycin against the liver cancer hepatoma cells and relationship to reactive oxygen species (ROS) generation. Materials and Methods: MCA-RH 7777 cells were treated with various combinations of duramycin concentrations and radiation doses. After the treatment, cell viabilities were determined by a cell proliferation assay; intracellular ROS levels were detected with the flow cytometric method. Results: MCA-RH 7777 cell viability was found significantly reduced after combining duramycin and radiation exposure (comparing to that of either treatment alone). Increased intracellular ROS levels were observed in cells treated with combinations of duramycin and radiation. Conclusion: Duramycin increased the intracellular ROS generation and also increased the radiosensitivity of MCA-RH 7777 cells.

Original languageEnglish (US)
Pages (from-to)543-546
Number of pages4
JournalJournal of Cancer Research and Therapeutics
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2021

Keywords

  • Duramycin
  • radiosensitivity
  • reactive oxygen species

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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