Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials

Yin Fang; Endao Han; Xin Xing Zhang; Yuanwen Jiang; Yiliang Lin; Jiuyun Shi; Jiangbo Wu; Lingyuan Meng; Xiang Gao; Philip J. Griffin; Xianghui Xiao; Hsiu Ming Tsai; Hua Zhou; Xiaobing Zuo; Qing Zhang; Miaoqi Chu; Qingteng Zhang; Ya Gao; Leah K. Roth; Reiner Bleher; Zhiyuan Ma; Zhang Jiang; Jiping Yue; Chien Min Kao; Chin Tu Chen; Andrei Tokmakoff; Jin Wang; Heinrich M. Jaeger; Bozhi Tian

doi:10.1016/j.matt.2020.01.008

Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials

Yin Fang^*, Endao Han, Xin Xing Zhang, Yuanwen Jiang, Yiliang Lin, Jiuyun Shi, Jiangbo Wu, Lingyuan Meng, Xiang Gao, Philip J. Griffin, Xianghui Xiao, Hsiu Ming Tsai, Hua Zhou, Xiaobing Zuo, Qing Zhang, Miaoqi Chu, Qingteng Zhang, Ya Gao, Leah K. Roth, Reiner BleherZhiyuan Ma, Zhang Jiang, Jiping Yue, Chien Min Kao, Chin Tu Chen, Andrei Tokmakoff, Jin Wang, Heinrich M. Jaeger, Bozhi Tian

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article

Abstract

Living tissues contain dense cellular ensembles and extracellular matrices (ECMs). Despite extensive efforts in the biomimetics field to develop ECM-like synthetic polymeric networks, a synthetic tissue-like material that can concurrently mimic the dynamic cellular- and ECM-level behaviors has yet to be achieved. Here, we demonstrate that cellular-scale hydrated starch granules, an underexplored component in materials science, can turn conventional hydrogels into tissue-like materials when composites are formed. The composites display programmability, anisotropy, strain-stiffening, mechanochemistry, and self-healability.

Original language	English (US)
Pages (from-to)	948-964
Number of pages	17
Journal	Matter
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.matt.2020.01.008
State	Published - Apr 1 2020

Keywords

MAP4: Demonstrate
X-ray tomography
biomimetics
composites
granular materials
hydrogel
memory
tissue-like
ultrasound shear-wave elastography

ASJC Scopus subject areas

Materials Science(all)

Access to Document

10.1016/j.matt.2020.01.008

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Fang, Y., Han, E., Zhang, X. X., Jiang, Y., Lin, Y., Shi, J., Wu, J., Meng, L., Gao, X., Griffin, P. J., Xiao, X., Tsai, H. M., Zhou, H., Zuo, X., Zhang, Q., Chu, M., Zhang, Q., Gao, Y., Roth, L. K., ... Tian, B. (2020). Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials. Matter, 2(4), 948-964. https://doi.org/10.1016/j.matt.2020.01.008

Fang, Yin ; Han, Endao ; Zhang, Xin Xing ; Jiang, Yuanwen ; Lin, Yiliang ; Shi, Jiuyun ; Wu, Jiangbo ; Meng, Lingyuan ; Gao, Xiang ; Griffin, Philip J. ; Xiao, Xianghui ; Tsai, Hsiu Ming ; Zhou, Hua ; Zuo, Xiaobing ; Zhang, Qing ; Chu, Miaoqi ; Zhang, Qingteng ; Gao, Ya ; Roth, Leah K. ; Bleher, Reiner ; Ma, Zhiyuan ; Jiang, Zhang ; Yue, Jiping ; Kao, Chien Min ; Chen, Chin Tu ; Tokmakoff, Andrei ; Wang, Jin ; Jaeger, Heinrich M. ; Tian, Bozhi. / Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials. In: Matter. 2020 ; Vol. 2, No. 4. pp. 948-964.

@article{047a5f04a415443faef63174b24a0acf,

title = "Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials",

abstract = "Living tissues contain dense cellular ensembles and extracellular matrices (ECMs). Despite extensive efforts in the biomimetics field to develop ECM-like synthetic polymeric networks, a synthetic tissue-like material that can concurrently mimic the dynamic cellular- and ECM-level behaviors has yet to be achieved. Here, we demonstrate that cellular-scale hydrated starch granules, an underexplored component in materials science, can turn conventional hydrogels into tissue-like materials when composites are formed. The composites display programmability, anisotropy, strain-stiffening, mechanochemistry, and self-healability.",

keywords = "MAP4: Demonstrate, X-ray tomography, biomimetics, composites, granular materials, hydrogel, memory, tissue-like, ultrasound shear-wave elastography",

author = "Yin Fang and Endao Han and Zhang, {Xin Xing} and Yuanwen Jiang and Yiliang Lin and Jiuyun Shi and Jiangbo Wu and Lingyuan Meng and Xiang Gao and Griffin, {Philip J.} and Xianghui Xiao and Tsai, {Hsiu Ming} and Hua Zhou and Xiaobing Zuo and Qing Zhang and Miaoqi Chu and Qingteng Zhang and Ya Gao and Roth, {Leah K.} and Reiner Bleher and Zhiyuan Ma and Zhang Jiang and Jiping Yue and Kao, {Chien Min} and Chen, {Chin Tu} and Andrei Tokmakoff and Jin Wang and Jaeger, {Heinrich M.} and Bozhi Tian",

year = "2020",

month = apr,

day = "1",

doi = "10.1016/j.matt.2020.01.008",

language = "English (US)",

volume = "2",

pages = "948--964",

journal = "Matter",

issn = "2590-2393",

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Fang, Y, Han, E, Zhang, XX, Jiang, Y, Lin, Y, Shi, J, Wu, J, Meng, L, Gao, X, Griffin, PJ, Xiao, X, Tsai, HM, Zhou, H, Zuo, X, Zhang, Q, Chu, M, Zhang, Q, Gao, Y, Roth, LK, Bleher, R, Ma, Z, Jiang, Z, Yue, J, Kao, CM, Chen, CT, Tokmakoff, A, Wang, J, Jaeger, HM & Tian, B 2020, 'Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials', Matter, vol. 2, no. 4, pp. 948-964. https://doi.org/10.1016/j.matt.2020.01.008

Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials. / Fang, Yin; Han, Endao; Zhang, Xin Xing; Jiang, Yuanwen; Lin, Yiliang; Shi, Jiuyun; Wu, Jiangbo; Meng, Lingyuan; Gao, Xiang; Griffin, Philip J.; Xiao, Xianghui; Tsai, Hsiu Ming; Zhou, Hua; Zuo, Xiaobing; Zhang, Qing; Chu, Miaoqi; Zhang, Qingteng; Gao, Ya; Roth, Leah K.; Bleher, Reiner; Ma, Zhiyuan; Jiang, Zhang; Yue, Jiping; Kao, Chien Min; Chen, Chin Tu; Tokmakoff, Andrei; Wang, Jin; Jaeger, Heinrich M.; Tian, Bozhi.

In: Matter, Vol. 2, No. 4, 01.04.2020, p. 948-964.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials

AU - Fang, Yin

AU - Han, Endao

AU - Zhang, Xin Xing

AU - Jiang, Yuanwen

AU - Lin, Yiliang

AU - Shi, Jiuyun

AU - Wu, Jiangbo

AU - Meng, Lingyuan

AU - Gao, Xiang

AU - Griffin, Philip J.

AU - Xiao, Xianghui

AU - Tsai, Hsiu Ming

AU - Zhou, Hua

AU - Zuo, Xiaobing

AU - Zhang, Qing

AU - Chu, Miaoqi

AU - Zhang, Qingteng

AU - Gao, Ya

AU - Roth, Leah K.

AU - Bleher, Reiner

AU - Ma, Zhiyuan

AU - Jiang, Zhang

AU - Yue, Jiping

AU - Kao, Chien Min

AU - Chen, Chin Tu

AU - Tokmakoff, Andrei

AU - Wang, Jin

AU - Jaeger, Heinrich M.

AU - Tian, Bozhi

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Living tissues contain dense cellular ensembles and extracellular matrices (ECMs). Despite extensive efforts in the biomimetics field to develop ECM-like synthetic polymeric networks, a synthetic tissue-like material that can concurrently mimic the dynamic cellular- and ECM-level behaviors has yet to be achieved. Here, we demonstrate that cellular-scale hydrated starch granules, an underexplored component in materials science, can turn conventional hydrogels into tissue-like materials when composites are formed. The composites display programmability, anisotropy, strain-stiffening, mechanochemistry, and self-healability.

AB - Living tissues contain dense cellular ensembles and extracellular matrices (ECMs). Despite extensive efforts in the biomimetics field to develop ECM-like synthetic polymeric networks, a synthetic tissue-like material that can concurrently mimic the dynamic cellular- and ECM-level behaviors has yet to be achieved. Here, we demonstrate that cellular-scale hydrated starch granules, an underexplored component in materials science, can turn conventional hydrogels into tissue-like materials when composites are formed. The composites display programmability, anisotropy, strain-stiffening, mechanochemistry, and self-healability.

KW - MAP4: Demonstrate

KW - X-ray tomography

KW - biomimetics

KW - composites

KW - granular materials

KW - hydrogel

KW - memory

KW - tissue-like

KW - ultrasound shear-wave elastography

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UR - http://www.scopus.com/inward/citedby.url?scp=85082432118&partnerID=8YFLogxK

U2 - 10.1016/j.matt.2020.01.008

DO - 10.1016/j.matt.2020.01.008

M3 - Article

AN - SCOPUS:85082432118

VL - 2

SP - 948

EP - 964

JO - Matter

JF - Matter

SN - 2590-2393

IS - 4

ER -