Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle

Teresa K. Woodruff*, Jo Beth D'Agostino, Neena B. Schwartz, Kelly E. Mayo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

224 Scopus citations

Abstract

The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and the ovary in turn produces specific hormonal signals for endocrine regulation. One such signal is inhibin, a heterodimeric protein that suppresses the secretion of follicle-stimulating hormone from pituitary gonadotrophs. Rat inhibin complementary DNA probes have been used to examine the levels and distribution of inhibin α- and βA-subunit messenger RNAs in the ovaries of cycling animals. Striking, dynamic changes have been found in inhibin messenger RNA accumulation during the developmental maturation of die ovarian follicle.

Original languageEnglish (US)
Pages (from-to)1296-1299
Number of pages4
JournalScience
Volume239
Issue number4846
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle'. Together they form a unique fingerprint.

Cite this