Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis

Margaret E. Walker-Caulfield, Julianne K. Hatfield, Melissa Ann Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrier (BBB) integrity and large-scale inflammation in the central nervous system (CNS). T cell infiltration into the meninges is observed in acute disease as well as during relapse, when neither BBB permeability nor significant increases in peripherally-derived immune cell numbers in the CNS are observed. These findings support the idea that the meninges are a gateway for immune cell access into the CNS, a finding that has important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalJournal of Neuroimmunology
Volume278
DOIs
StatePublished - Jan 15 2015

Keywords

  • Blood brain barrier (BBB)
  • CNS demyelinating disease
  • Experimental autoimmune encephalomyelitis (EAE)
  • Meninges
  • Multiple sclerosis (MS)
  • Relapsing-remitting EAE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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