Dynamic display of bioactivity through host-guest chemistry

Job Boekhoven, Charles M. Rubertpérez, Shantanu Sur, Amanda Worthy, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

Original languageEnglish (US)
Pages (from-to)12077-12080
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number46
StatePublished - Nov 11 2013


  • biological signaling
  • cell adhesion
  • dynamics
  • host-guest chemistry
  • supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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