Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation

Joby J. Westmoreland, Yiannis Drosos, Jacqueline Kelly, Jianming Ye, Anna L. Means, M. Kay Washington, Beatriz Sosa-Pineda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has been found to correlate with some diseases, tumor progression, and defective morphogenesis. Investigating the pattern of claudin expression during embryogenesis or in certain pathological conditions is necessary to begin disclosing the role of these proteins in health and disease. Results: This study analyzed the expression of several claudins during mouse pancreas organogenesis and in pancreatic intraepithelial neoplasias of mouse and human origin. Conclusions: Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)583-594
Number of pages12
JournalDevelopmental Dynamics
Volume241
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Claudin
  • Development
  • Pancreas
  • Pancreatic intraepithelial neoplasia
  • Tight junction

ASJC Scopus subject areas

  • Developmental Biology

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