Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Chun Shu Piao, Young Mi Yu, Pyung Lim Han, Ja Kyeong Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalBrain research
Volume976
Issue number1
DOIs
StatePublished - Jun 20 2003

Keywords

  • Astrocyte
  • Delayed neuronal death
  • Focal ischemia
  • p38β MAPK

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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