Dynamic hydrogels: Translating a protein conformational change into macroscopic motion

William L. Murphy*, W. Shannon Dillmore, Justin Modica, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

(Figure Presented) Natural inspiration: A bioinspired functional material in the form of a hydrogel created by cross-linking an engineered version of calmodulin, a protein which undergoes a conformational change in response to ligand binding (see schematic representation), with a four-armed polyethylene glycol) molecule terminated with acrylate groups decreased in volume by 20% when treated with the ligand trifluoperazine. Multiple cycles of gel swelling and shrinkage were possible.

Original languageEnglish (US)
Pages (from-to)3066-3069
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number17
DOIs
StatePublished - Jun 29 2007

Keywords

  • Biomaterials
  • Gels
  • Proteins
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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