Dynamic manipulation and patterning of breast cancer cells in biosolution

Hao Jia, Hao Tang, Anika Rede, Xia Liu, Huiping Liu, Philip X.L. Feng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.

Original languageEnglish (US)
Title of host publication2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages569-572
Number of pages4
ISBN (Electronic)9781509050789
DOIs
StatePublished - Feb 23 2017
Event30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States
Duration: Jan 22 2017Jan 26 2017

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
CountryUnited States
CityLas Vegas
Period1/22/171/26/17

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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