Dynamic organization of pre-mRNA splicing factors

S. Huang, D. L. Spector*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Studies from several laboratories during the past few years have increased our understanding towards the dynamic organization of pre-mRNA splicing factors in the mammalian cell nucleus. Many well characterized splicing factors have been localized in a speckled pattern in the cell nucleus. Upon the activation of RNA polymerase II transcription, splicing factors are recruited to the sites of transcription from sites of reassembly and/or storage. Nascent intron- containing RNA transcripts are spliced at the sites of transcription. The speckled distribution of splicing factors in the nucleus is altered when either transcription or pre-mRNA splicing activities are interrupted suggesting that the organization of the splicing machinery in the interphase nucleus is a direct reflection of the transcriptional activity of the cell.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Cellular Biochemistry
Volume62
Issue number2
DOIs
StatePublished - Aug 1996

Keywords

  • interchromatin granule clusters
  • nuclear structure
  • perichromatin fibrils
  • speckled distribution
  • splicing factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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