Dynamic regulation of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications

Marc P. Lussier, Antonio Sanz-Clemente, Katherine W. Roche*

*Corresponding author for this work

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory. During the last decade, posttranslational modifications have emerged ascritical regulators of synaptic transmission and plasticity. Notably, phosphorylation, ubiquitination, and palmitoylation control the stability, trafficking, and synaptic expression of glutamate receptors in the central nervous system. In the current review, we will summarize some of the progress made by the neuroscience community regarding our understanding of phosphorylation, ubiquitination, and palmitoylation of the NMDA and AMPA subtypes of glutamate receptors.

Original languageEnglish (US)
Pages (from-to)28596-28603
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number48
DOIs
StatePublished - Nov 27 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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