TY - JOUR
T1 - Dynamic remodeling of transcription complexes by molecular chaperones
AU - Morimoto, Richard I.
PY - 2002/8/9
Y1 - 2002/8/9
N2 - The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.
AB - The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.
UR - http://www.scopus.com/inward/record.url?scp=0037047429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037047429&partnerID=8YFLogxK
U2 - 10.1016/S0092-8674(02)00860-7
DO - 10.1016/S0092-8674(02)00860-7
M3 - Review article
C2 - 12176314
AN - SCOPUS:0037047429
SN - 0092-8674
VL - 110
SP - 281
EP - 284
JO - Cell
JF - Cell
IS - 3
ER -