Dynamic remodeling of transcription complexes by molecular chaperones

Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview article

148 Scopus citations

Abstract

The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalCell
Volume110
Issue number3
DOIs
StatePublished - Aug 9 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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