Dynamic substrates for cell biology

Pradeep Bugga, Milan Mrksich*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Scopus citations


The interactions of adherent cells with their insoluble extracellular matrices are complex and challenging to study in the laboratory. Approaches from interface science have been important to preparing models of the biological matrix wherein discrete ligands are immobilized and interact with cellular receptors. A recent theme has been to develop dynamic substrates, where the activities of immobilized ligands can be modulated in real-time during cell culture. This short opinion reviews the strategies to manipulate ligand activity, highlights recent work that has advanced the field and discusses the applications that have been enabled. This work suggests that dynamic substrates will continue to find important uses in basic and applied biointerfaces.

Original languageEnglish (US)
Pages (from-to)80-87
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
StatePublished - Nov 2018


  • Biointerfaces
  • Cell migration
  • Cell patterning
  • Self-assembled monolayer

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry

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