Dynamic substrates to investigate cell migration

Srivatsan Raghavan*, Youngeun Kwon, Milan Mrksich, Christopher S. Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic migration events involving populations of cells are critical to in vivo morphogenetic processes such as angiogenesis and wound healing. It is clear that the formation of new adhesions, cell spreading, and invasion into new territory depend upon the composition and architecture of the extracellular matrix (ECM), and on the types and spatial organization of cells involved. However, traditional methods of studying migratory processes, for example scrape wounding monolayers of cells, provide little control over these structural and organizational parameters. We have developed microcontact printing methods to pattern culture substrates with regions that are adhesive to cells, regions that are not adhesive, and regions that can be dynamically switched from a non-adhesive to cell-adhesive state. We will present the development of these novel dynamic substrates and our preliminary studies into how monolayer geometry regulates the migration of groups of cells as they respond to changes in their adhesive environment.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Pages886-887
Number of pages2
StatePublished - 2005
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: Jun 22 2005Jun 26 2005

Publication series

NameProceedings of the 2005 Summer Bioengineering Conference
Volume2005

Other

Other2005 Summer Bioengineering Conference
CountryUnited States
CityVail, CO
Period6/22/056/26/05

ASJC Scopus subject areas

  • Engineering(all)

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