Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping

Noriyuki Ohkura; Kazuo Kasahara; Satoshi Watanabe; Johsuke Hara; Miki Abo; Takashi Sone; Hideharu Kimura; Munehisa Takata; Masaya Tamura; Isao Matsumoto; Yusuke Nakade; Shigeru Sanada; Rie Tanaka

doi:10.1159/000506881

Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping

Noriyuki Ohkura^*, Kazuo Kasahara, Satoshi Watanabe, Johsuke Hara, Miki Abo, Takashi Sone, Hideharu Kimura, Munehisa Takata, Masaya Tamura, Isao Matsumoto, Yusuke Nakade, Shigeru Sanada, Rie Tanaka

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective: The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. Methods: One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. Results: The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (r = 0.48, p < 0.01) and the percentage of the predicted FEV₁ (r = -0.33, p < 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV₁-dependent manner. Conclusion: The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.

Original language	English (US)
Pages (from-to)	382-388
Number of pages	7
Journal	Respiration
Volume	99
Issue number	5
DOIs	https://doi.org/10.1159/000506881
State	Published - May 1 2020

Keywords

Air flow limitation
Chronic obstructive pulmonary disease
Digital radiography
Lung area changes
Pulmonary function

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000506881

Cite this

@article{c8c93a7359a84316a91c45f95c454c26,

title = "Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping",

abstract = "Objective: The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. Methods: One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. Results: The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (r = 0.48, p < 0.01) and the percentage of the predicted FEV1 (r = -0.33, p < 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV1-dependent manner. Conclusion: The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.",

keywords = "Air flow limitation, Chronic obstructive pulmonary disease, Digital radiography, Lung area changes, Pulmonary function",

author = "Noriyuki Ohkura and Kazuo Kasahara and Satoshi Watanabe and Johsuke Hara and Miki Abo and Takashi Sone and Hideharu Kimura and Munehisa Takata and Masaya Tamura and Isao Matsumoto and Yusuke Nakade and Shigeru Sanada and Rie Tanaka",

note = "Funding Information: This study was supported in part by Konica Minolta, Inc. (Tokyo, Japan). Publisher Copyright: {\textcopyright} 2020 S. Karger AG, Basel.",

year = "2020",

month = may,

day = "1",

doi = "10.1159/000506881",

language = "English (US)",

volume = "99",

pages = "382--388",

journal = "Respiration",

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T1 - Dynamic-Ventilatory Digital Radiography in Air Flow Limitation

T2 - A Change in Lung Area Reflects Air Trapping

AU - Ohkura, Noriyuki

AU - Kasahara, Kazuo

AU - Watanabe, Satoshi

AU - Hara, Johsuke

AU - Abo, Miki

AU - Sone, Takashi

AU - Kimura, Hideharu

AU - Takata, Munehisa

AU - Tamura, Masaya

AU - Matsumoto, Isao

AU - Nakade, Yusuke

AU - Sanada, Shigeru

AU - Tanaka, Rie

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Objective: The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. Methods: One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. Results: The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (r = 0.48, p < 0.01) and the percentage of the predicted FEV1 (r = -0.33, p < 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV1-dependent manner. Conclusion: The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.

AB - Objective: The aim of this study was to determine the utility of dynamic-ventilatory digital radiography (DR) for pulmonary function assessment in patients with airflow limitation. Methods: One hundred and eighteen patients with airflow limitation (72 patients with lung cancer before surgery, 35 patients with chronic obstructive pulmonary disease [COPD], 6 patients with asthma, and 5 patients with asthma-COPD overlap syndrome) were assessed with dynamic-ventilatory DR. The patients were instructed to inhale and exhale slowly and maximally. Sequential chest X-ray images were captured in 15 frames per second using a dynamic flat-panel imaging system. The relationship between the lung area and the rate of change in the lung area due to respiratory motion with respect to pulmonary function was analyzed. Results: The rate of change in the lung area from maximum inspiration to maximum expiration (Rs ratio) was associated with the RV/TLC ratio (r = 0.48, p < 0.01) and the percentage of the predicted FEV1 (r = -0.33, p < 0.01) in patients with airflow limitations. The Rs ratio also decreased in an FEV1-dependent manner. Conclusion: The rate of change in the lung area due to respiratory motion evaluated with dynamic DR reflects air trapping. Dynamic DR is a potential tool for the comprehensive assessment of pulmonary function in patients with COPD.

KW - Air flow limitation

KW - Chronic obstructive pulmonary disease

KW - Digital radiography

KW - Lung area changes

KW - Pulmonary function

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Dynamic-Ventilatory Digital Radiography in Air Flow Limitation: A Change in Lung Area Reflects Air Trapping

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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