Dynamic vortical flow profile quantitatively characterizes mitral valvular-left ventricular hemodynamic coupling: In vivo analysis by dynamic 3D enstrophy mapping from 4D Flow MRI

Mohammed S.M. Elbaz*, Trung Bao Le, Pankaj Garg, Arno A.W. Roest, Boudewijn P.F. Lelieveldt, Sven Plein, Jos J.M. Westenberg, Fotis Sotiropoulos, Rob J. van der Geest

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vortical blood flow in the human left ventricular (LV) inflow initiates from the mitral valve (MV) and evolves within the LV during diastolic E-filling. Hence, vortical flow links MV and LV hemodynamics. This study sought to elucidate and quantitatively characterize the in vivo 3D dynamics of LV vortical flow over E-filling and relation to MV-LV hemodynamic coupling using 4D Flow MRI flow field. 34 healthy volunteers and 5 example patients underwent 4D Flow MRI. Vortical blood flow evolution was mapped in the LV over E-wave using enstrophy density. A new dimensionless profile PMV-LV was derived as a function of both MV vortex formation time (VFT) and LV volumetric enstrophy density. Results reveal that 3D vortical flow evolution in the healthy LV follows a bi-phasic behavior with a vortical growth phase followed by a vortical decay phase. In healthy LVs studied, the PMV-LV profile showed that the vortical growth and decay phases are characterized by a vortical growth time Tgrowth = 1.23 ± 0.25, growth rate α = 0.80 ± 0.17, decay time Tdecay = 0.96 ± 0.39 and decay rate β = -1.02 ± 0.49. Distinctly altered parameters were found in the pilot patients studied. The derived PMV-LV profile quantitatively characterizes MV-LV hemodynamic coupling by vortical flow dynamics. Results herein unravel new insights into cardiac physiology and could enable a novel standardized methodology to study MV-LV hemodynamic coupling and association to cardiac function in health and disease.

Original languageEnglish (US)
JournalUnknown Journal
StatePublished - Oct 10 2018

Keywords

  • 4D Flow MRI
  • Cardiac blood flow
  • Cardiac function
  • Cardiac hemodynamics
  • Heart physiology
  • Hemodynamic coupling
  • Left ventricle
  • Mitral valve
  • Vortex flow

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Dynamic vortical flow profile quantitatively characterizes mitral valvular-left ventricular hemodynamic coupling: In vivo analysis by dynamic 3D enstrophy mapping from 4D Flow MRI'. Together they form a unique fingerprint.

Cite this