Dynamically restructuring hydrogel networks formed with reversible covalent crosslinks

Meredith C. Roberts*, Melissa C. Hanson, Archna P. Massey, Elliott A. Karren, Patrick F. Kiser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


A study was conducted to demonstrate the synthesis hydrogel networks that formed in the physiological pH range, using reversible covalent crosslinked gels. The crosslinked gels demonstrated a spectrum of pH-dependent viscoelastic behavior that can be controlled by the chemical composition of the polymer backbone. The reversible crosslinked gels also allowed the hydrogel networks,to restructure dynamically and self-heal after mechanical disruption. Phenylboronate-salicylhydroxamate gels were used as a new class of reversible crosslinked gels, enabling precise control over network viscoelasticity and pH responsiveness. Gel behavior was quantified by subjecting them to dynamic rheology, as a function of angular frequency. It was also observed that the rheological behavior of the new class of crosslinked gels was consistent with the time-dependent viscoelastic properties of dynamic hydrogel networks.

Original languageEnglish (US)
Pages (from-to)2503-2507
Number of pages5
JournalAdvanced Materials
Issue number18
StatePublished - Sep 17 2007

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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