Dynamics and efficiency of DNA hole transport via alternating AT versus poIy(A) sequences

Frederick D. Lewis; Pierre Daublain; Boiko Cohen; Josh Vura-Weis; Vladimir Shafirovich; Michael R. Wasielewski

doi:10.1021/ja076876o

Dynamics and efficiency of DNA hole transport via alternating AT versus poIy(A) sequences

Frederick D. Lewis^*, Pierre Daublain, Boiko Cohen, Josh Vura-Weis, Vladimir Shafirovich, Michael R. Wasielewski

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The dynamics and efficiencies of photoinduced charge separation across alternating AT, ATA, ATAT, and ATATA base pair sequences in synthetic DNA hairpins have been determined by means of femtosecond time-resolved transient absorption spectroscopy. When compared to our results for charge transport across poly(A) sequences, both the rate constants and efficiencies are lower for the poly(AT) sequences, especially at short distances (3 or 4 base pairs). At longer distances, charge separation becomes weakly distance-dependent for poly(AT) as well as poly(A) sequences. Both the poly(AT) and poly(A) sequences undergo charge separation via a multistep mechanism consisting of photochemical hole injection into the neighboring A followed by hole transport and hole trapping.

Original language	English (US)
Pages (from-to)	15130-15131
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	49
DOIs	https://doi.org/10.1021/ja076876o
State	Published - Dec 12 2007

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja076876o

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abstract = "The dynamics and efficiencies of photoinduced charge separation across alternating AT, ATA, ATAT, and ATATA base pair sequences in synthetic DNA hairpins have been determined by means of femtosecond time-resolved transient absorption spectroscopy. When compared to our results for charge transport across poly(A) sequences, both the rate constants and efficiencies are lower for the poly(AT) sequences, especially at short distances (3 or 4 base pairs). At longer distances, charge separation becomes weakly distance-dependent for poly(AT) as well as poly(A) sequences. Both the poly(AT) and poly(A) sequences undergo charge separation via a multistep mechanism consisting of photochemical hole injection into the neighboring A followed by hole transport and hole trapping.",

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AU - Shafirovich, Vladimir

AU - Wasielewski, Michael R.

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