Dynamics of directional plasticity in the human vertical vestibulo-ocular reflex

G. C.Y. Peng*, J. F. Baker, B. W. Peterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Directional plasticity of the human vestibulo-ocular reflex (VOR) was studied in 10 subjects. The adaptation paradigm coupled 0.25 Hz, 19°/s vertical pitch vestibular rotations with 28°/s horizontal optokinetic oscillations. Electro-oculographic recordings in the dark were taken at 0.05, 0.1, 0.25, 0.5, and 1 Hz pitch rotations before and after training and at 15-minute intervals during 0.25 Hz adaptation. Peak head velocity was kept at 19°/sec for frequencies above 0.1 Hz, while constant amplitude was maintained at ±24° for 0.05 and 0.1 Hz. In all subjects, directional training produced slow phase horizontal VOR eye movements that were not present during vertical rotations before adaptation. During the 2-hour training period, the cross-axis VOR gain at 0.25 Hz increased up to 0.16. Adaptive VOR gain was highest at the lowest frequency and reached a tuned peak at the 0.25 Hz training frequency. Cross-axis VOR phase remained around 0° at higher frequencies and lagged at lower frequencies. In all subjects, the cross-axis VOR gain was diminished when subjects were exposed to 0.25 Hz pitch rotations paired with a stationary visual field. The dynamics of the vertical VOR remained constant throughout the experiment.These results are further evidence that the frequency response characteristics of adaptive cross-axis VOR gain are similar in humans and cats, while phase behavior is less complexin humans. The high adaptive gain at low frequencies implicates otolith contributions during cross-axis adaptation.

Original languageEnglish (US)
Pages (from-to)453-460
Number of pages8
JournalJournal of Vestibular Research: Equilibrium and Orientation
Volume4
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Adaptation
  • Eye movements
  • Vestibulo-ocular reflex
  • Vestibulo-ocular reflex plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

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