Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older

The LIFE Study

Mylène Aubertin-Leheudre*, Stephen Anton, Daniel P. Beavers, Todd M. Manini, Roger Fielding, Ann Newman, Tim Church, Stephen B. Kritchevsky, David Conroy, Mary M. McDermott, Anda Botoseneanu, Michelle E. Hauser, Marco Pahor, Thomas Gill, Carlos Fragoso, Roger Fielding, Michelle E. Hauser, Marco Pahor, Jack M. Guralnik, Christiaan Leeuwenburgh & 150 others Connie Caudle, Lauren Crump, Latonia Holmes, Jocelyn Lee, Ching ju Lu, Michael E. Miller, Mark A. Espeland, Walter T. Ambrosius, William Applegate, Daniel P. Beavers, Robert P. Byington, Delilah Cook, Curt D. Furberg, Lea N. Harvin, Leora Henkin, Med John Hepler, Fang Chi Hsu, Laura Lovato, Wesley Roberson, Julia Rushing, Scott Rushing, Cynthia L. Stowe, Michael P. Walkup, Don Hire, W. Jack Rejeski, Jeffrey A. Katula, Peter H. Brubaker, Shannon L. Mihalko, Janine M. Jennings, Evan C. Hadley, Sergei Romashkan, Kushang V. Patel, Denise Bonds, Mary M. McDermott, Bonnie Spring, Joshua Hauser, Diana Kerwin, Kathryn Domanchuk, Rex Graff, Alvito Rego, Timothy S. Church, Steven N. Blair, Valerie H. Myers, Ron Monce, Nathan E. Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Rodarte, Heidi K. Millet, Catrine Tudor-Locke, Ben P. Butitta, Sheletta G. Donatto, Shannon H. Cocreham, Abby C. King, Cynthia M. Castro, William L. Haskell, Randall S. Stafford, Leslie A. Pruitt, Kathy Berra, Veronica Yank, Roger A. Fielding, Miriam E. Nelson, Sara C. Folta, Edward M. Phillips, Christine K. Liu, Erica C. McDavitt, Kieran F. Reid, Dylan R. Kirn, Evan P. Pasha, Won S. Kim, Vince E. Beard, Eleni X. Tsiroyannis, Cynthia Hau, Todd M. Manini, Marco Pahor, Stephen D. Anton, Susan Nayfield, Thomas W. Buford, Michael Marsiske, Bhanuprasad D. Sandesara, Jeffrey D. Knaggs, Megan S. Lorow, William C. Marena, Irina Korytov, Holly L. Morris, Margo Fitch, Floris F. Singletary, Jackie Causer, Katie A. Radcliff, Anne B. Newman, Stephanie A. Studenski, Bret H. Goodpaster, Nancy W. Glynn, Oscar Lopez, Neelesh K. Nadkarni, Kathy Williams, Mark A. Newman, George Grove, Janet T. Bonk, Jennifer Rush, Piera Kost, Diane G. Ives, Stephen B. Kritchevsky, Anthony P. Marsh, Tina E. Brinkley, Jamehl S. Demons, Kaycee M. Sink, Kimberly Kennedy, Rachel Shertzer-Skinner, Abbie Wrights, Rose Fries, Deborah Barr, Thomas M. Gill, Robert S. Axtell, Susan S. Kashaf, Nathalie de Rekeneire, Joanne M. McGloin, Karen C. Wu, Denise M. Shepard, Barbara Fennelly, Lynne P. Iannone, Raeleen Mautner, Theresa Sweeney Barnett, Sean N. Halpin, Matthew J. Brennan, Julie A. Bugaj, Maria A. Zenoni, Bridget M. Mignosa, Jeff Williamson, Kaycee M. Sink, Hugh C. Hendrie, Stephen R. Rapp, Joe Verghese, Nancy Woolard, Mark Espeland, Janine Jennings, Valerie K. Wilson, Carl J. Pepine, Mario Ariet, Eileen Handberg, Daniel Deluca, James Hill, Anita Szady, Geoffrey L. Chupp, Gail M. Flynn, Thomas M. Gill, John L. Hankinson, Carlos A. Vaz Fragoso, Erik J. Groessl, Robert M. Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalJournal of the American Medical Directors Association
Volume18
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Life Style
Blood Pressure
Health
Waist Circumference
Abdominal Obesity
Metabolic Diseases
National Institutes of Health (U.S.)
Muscle Strength
Fasting
Body Mass Index
Obesity
Odds Ratio
Confidence Intervals
Hypertension
Lipids
Glucose

Keywords

  • Muscle strength
  • aging
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Nursing(all)
  • Health Policy
  • Geriatrics and Gerontology

Cite this

Aubertin-Leheudre, M., Anton, S., Beavers, D. P., Manini, T. M., Fielding, R., Newman, A., ... Kaplan, R. M. (2017). Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal of the American Medical Directors Association, 18(4), 312-319. https://doi.org/10.1016/j.jamda.2016.10.001
Aubertin-Leheudre, Mylène ; Anton, Stephen ; Beavers, Daniel P. ; Manini, Todd M. ; Fielding, Roger ; Newman, Ann ; Church, Tim ; Kritchevsky, Stephen B. ; Conroy, David ; McDermott, Mary M. ; Botoseneanu, Anda ; Hauser, Michelle E. ; Pahor, Marco ; Gill, Thomas ; Fragoso, Carlos ; Fielding, Roger ; Hauser, Michelle E. ; Pahor, Marco ; Guralnik, Jack M. ; Leeuwenburgh, Christiaan ; Caudle, Connie ; Crump, Lauren ; Holmes, Latonia ; Lee, Jocelyn ; Lu, Ching ju ; Miller, Michael E. ; Espeland, Mark A. ; Ambrosius, Walter T. ; Applegate, William ; Beavers, Daniel P. ; Byington, Robert P. ; Cook, Delilah ; Furberg, Curt D. ; Harvin, Lea N. ; Henkin, Leora ; Hepler, Med John ; Hsu, Fang Chi ; Lovato, Laura ; Roberson, Wesley ; Rushing, Julia ; Rushing, Scott ; Stowe, Cynthia L. ; Walkup, Michael P. ; Hire, Don ; Rejeski, W. Jack ; Katula, Jeffrey A. ; Brubaker, Peter H. ; Mihalko, Shannon L. ; Jennings, Janine M. ; Hadley, Evan C. ; Romashkan, Sergei ; Patel, Kushang V. ; Bonds, Denise ; McDermott, Mary M. ; Spring, Bonnie ; Hauser, Joshua ; Kerwin, Diana ; Domanchuk, Kathryn ; Graff, Rex ; Rego, Alvito ; Church, Timothy S. ; Blair, Steven N. ; Myers, Valerie H. ; Monce, Ron ; Britt, Nathan E. ; Harris, Melissa Nauta ; McGucken, Ami Parks ; Rodarte, Ruben ; Millet, Heidi K. ; Tudor-Locke, Catrine ; Butitta, Ben P. ; Donatto, Sheletta G. ; Cocreham, Shannon H. ; King, Abby C. ; Castro, Cynthia M. ; Haskell, William L. ; Stafford, Randall S. ; Pruitt, Leslie A. ; Berra, Kathy ; Yank, Veronica ; Fielding, Roger A. ; Nelson, Miriam E. ; Folta, Sara C. ; Phillips, Edward M. ; Liu, Christine K. ; McDavitt, Erica C. ; Reid, Kieran F. ; Kirn, Dylan R. ; Pasha, Evan P. ; Kim, Won S. ; Beard, Vince E. ; Tsiroyannis, Eleni X. ; Hau, Cynthia ; Manini, Todd M. ; Pahor, Marco ; Anton, Stephen D. ; Nayfield, Susan ; Buford, Thomas W. ; Marsiske, Michael ; Sandesara, Bhanuprasad D. ; Knaggs, Jeffrey D. ; Lorow, Megan S. ; Marena, William C. ; Korytov, Irina ; Morris, Holly L. ; Fitch, Margo ; Singletary, Floris F. ; Causer, Jackie ; Radcliff, Katie A. ; Newman, Anne B. ; Studenski, Stephanie A. ; Goodpaster, Bret H. ; Glynn, Nancy W. ; Lopez, Oscar ; Nadkarni, Neelesh K. ; Williams, Kathy ; Newman, Mark A. ; Grove, George ; Bonk, Janet T. ; Rush, Jennifer ; Kost, Piera ; Ives, Diane G. ; Kritchevsky, Stephen B. ; Marsh, Anthony P. ; Brinkley, Tina E. ; Demons, Jamehl S. ; Sink, Kaycee M. ; Kennedy, Kimberly ; Shertzer-Skinner, Rachel ; Wrights, Abbie ; Fries, Rose ; Barr, Deborah ; Gill, Thomas M. ; Axtell, Robert S. ; Kashaf, Susan S. ; de Rekeneire, Nathalie ; McGloin, Joanne M. ; Wu, Karen C. ; Shepard, Denise M. ; Fennelly, Barbara ; Iannone, Lynne P. ; Mautner, Raeleen ; Barnett, Theresa Sweeney ; Halpin, Sean N. ; Brennan, Matthew J. ; Bugaj, Julie A. ; Zenoni, Maria A. ; Mignosa, Bridget M. ; Williamson, Jeff ; Sink, Kaycee M. ; Hendrie, Hugh C. ; Rapp, Stephen R. ; Verghese, Joe ; Woolard, Nancy ; Espeland, Mark ; Jennings, Janine ; Wilson, Valerie K. ; Pepine, Carl J. ; Ariet, Mario ; Handberg, Eileen ; Deluca, Daniel ; Hill, James ; Szady, Anita ; Chupp, Geoffrey L. ; Flynn, Gail M. ; Gill, Thomas M. ; Hankinson, John L. ; Vaz Fragoso, Carlos A. ; Groessl, Erik J. ; Kaplan, Robert M. / Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older : The LIFE Study. In: Journal of the American Medical Directors Association. 2017 ; Vol. 18, No. 4. pp. 312-319.
@article{28ae83145d81401ab0c0a97b1f96f7d7,
title = "Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study",
abstract = "Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1{\%}, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95{\%} confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.",
keywords = "Muscle strength, aging, metabolic syndrome, obesity",
author = "Myl{\`e}ne Aubertin-Leheudre and Stephen Anton and Beavers, {Daniel P.} and Manini, {Todd M.} and Roger Fielding and Ann Newman and Tim Church and Kritchevsky, {Stephen B.} and David Conroy and McDermott, {Mary M.} and Anda Botoseneanu and Hauser, {Michelle E.} and Marco Pahor and Thomas Gill and Carlos Fragoso and Roger Fielding and Hauser, {Michelle E.} and Marco Pahor and Guralnik, {Jack M.} and Christiaan Leeuwenburgh and Connie Caudle and Lauren Crump and Latonia Holmes and Jocelyn Lee and Lu, {Ching ju} and Miller, {Michael E.} and Espeland, {Mark A.} and Ambrosius, {Walter T.} and William Applegate and Beavers, {Daniel P.} and Byington, {Robert P.} and Delilah Cook and Furberg, {Curt D.} and Harvin, {Lea N.} and Leora Henkin and Hepler, {Med John} and Hsu, {Fang Chi} and Laura Lovato and Wesley Roberson and Julia Rushing and Scott Rushing and Stowe, {Cynthia L.} and Walkup, {Michael P.} and Don Hire and Rejeski, {W. Jack} and Katula, {Jeffrey A.} and Brubaker, {Peter H.} and Mihalko, {Shannon L.} and Jennings, {Janine M.} and Hadley, {Evan C.} and Sergei Romashkan and Patel, {Kushang V.} and Denise Bonds and McDermott, {Mary M.} and Bonnie Spring and Joshua Hauser and Diana Kerwin and Kathryn Domanchuk and Rex Graff and Alvito Rego and Church, {Timothy S.} and Blair, {Steven N.} and Myers, {Valerie H.} and Ron Monce and Britt, {Nathan E.} and Harris, {Melissa Nauta} and McGucken, {Ami Parks} and Ruben Rodarte and Millet, {Heidi K.} and Catrine Tudor-Locke and Butitta, {Ben P.} and Donatto, {Sheletta G.} and Cocreham, {Shannon H.} and King, {Abby C.} and Castro, {Cynthia M.} and Haskell, {William L.} and Stafford, {Randall S.} and Pruitt, {Leslie A.} and Kathy Berra and Veronica Yank and Fielding, {Roger A.} and Nelson, {Miriam E.} and Folta, {Sara C.} and Phillips, {Edward M.} and Liu, {Christine K.} and McDavitt, {Erica C.} and Reid, {Kieran F.} and Kirn, {Dylan R.} and Pasha, {Evan P.} and Kim, {Won S.} and Beard, {Vince E.} and Tsiroyannis, {Eleni X.} and Cynthia Hau and Manini, {Todd M.} and Marco Pahor and Anton, {Stephen D.} and Susan Nayfield and Buford, {Thomas W.} and Michael Marsiske and Sandesara, {Bhanuprasad D.} and Knaggs, {Jeffrey D.} and Lorow, {Megan S.} and Marena, {William C.} and Irina Korytov and Morris, {Holly L.} and Margo Fitch and Singletary, {Floris F.} and Jackie Causer and Radcliff, {Katie A.} and Newman, {Anne B.} and Studenski, {Stephanie A.} and Goodpaster, {Bret H.} and Glynn, {Nancy W.} and Oscar Lopez and Nadkarni, {Neelesh K.} and Kathy Williams and Newman, {Mark A.} and George Grove and Bonk, {Janet T.} and Jennifer Rush and Piera Kost and Ives, {Diane G.} and Kritchevsky, {Stephen B.} and Marsh, {Anthony P.} and Brinkley, {Tina E.} and Demons, {Jamehl S.} and Sink, {Kaycee M.} and Kimberly Kennedy and Rachel Shertzer-Skinner and Abbie Wrights and Rose Fries and Deborah Barr and Gill, {Thomas M.} and Axtell, {Robert S.} and Kashaf, {Susan S.} and {de Rekeneire}, Nathalie and McGloin, {Joanne M.} and Wu, {Karen C.} and Shepard, {Denise M.} and Barbara Fennelly and Iannone, {Lynne P.} and Raeleen Mautner and Barnett, {Theresa Sweeney} and Halpin, {Sean N.} and Brennan, {Matthew J.} and Bugaj, {Julie A.} and Zenoni, {Maria A.} and Mignosa, {Bridget M.} and Jeff Williamson and Sink, {Kaycee M.} and Hendrie, {Hugh C.} and Rapp, {Stephen R.} and Joe Verghese and Nancy Woolard and Mark Espeland and Janine Jennings and Wilson, {Valerie K.} and Pepine, {Carl J.} and Mario Ariet and Eileen Handberg and Daniel Deluca and James Hill and Anita Szady and Chupp, {Geoffrey L.} and Flynn, {Gail M.} and Gill, {Thomas M.} and Hankinson, {John L.} and {Vaz Fragoso}, {Carlos A.} and Groessl, {Erik J.} and Kaplan, {Robert M.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.jamda.2016.10.001",
language = "English (US)",
volume = "18",
pages = "312--319",
journal = "Journal of the American Medical Directors Association",
issn = "1525-8610",
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}

Aubertin-Leheudre, M, Anton, S, Beavers, DP, Manini, TM, Fielding, R, Newman, A, Church, T, Kritchevsky, SB, Conroy, D, McDermott, MM, Botoseneanu, A, Hauser, ME, Pahor, M, Gill, T, Fragoso, C, Fielding, R, Hauser, ME, Pahor, M, Guralnik, JM, Leeuwenburgh, C, Caudle, C, Crump, L, Holmes, L, Lee, J, Lu, CJ, Miller, ME, Espeland, MA, Ambrosius, WT, Applegate, W, Beavers, DP, Byington, RP, Cook, D, Furberg, CD, Harvin, LN, Henkin, L, Hepler, MJ, Hsu, FC, Lovato, L, Roberson, W, Rushing, J, Rushing, S, Stowe, CL, Walkup, MP, Hire, D, Rejeski, WJ, Katula, JA, Brubaker, PH, Mihalko, SL, Jennings, JM, Hadley, EC, Romashkan, S, Patel, KV, Bonds, D, McDermott, MM, Spring, B, Hauser, J, Kerwin, D, Domanchuk, K, Graff, R, Rego, A, Church, TS, Blair, SN, Myers, VH, Monce, R, Britt, NE, Harris, MN, McGucken, AP, Rodarte, R, Millet, HK, Tudor-Locke, C, Butitta, BP, Donatto, SG, Cocreham, SH, King, AC, Castro, CM, Haskell, WL, Stafford, RS, Pruitt, LA, Berra, K, Yank, V, Fielding, RA, Nelson, ME, Folta, SC, Phillips, EM, Liu, CK, McDavitt, EC, Reid, KF, Kirn, DR, Pasha, EP, Kim, WS, Beard, VE, Tsiroyannis, EX, Hau, C, Manini, TM, Pahor, M, Anton, SD, Nayfield, S, Buford, TW, Marsiske, M, Sandesara, BD, Knaggs, JD, Lorow, MS, Marena, WC, Korytov, I, Morris, HL, Fitch, M, Singletary, FF, Causer, J, Radcliff, KA, Newman, AB, Studenski, SA, Goodpaster, BH, Glynn, NW, Lopez, O, Nadkarni, NK, Williams, K, Newman, MA, Grove, G, Bonk, JT, Rush, J, Kost, P, Ives, DG, Kritchevsky, SB, Marsh, AP, Brinkley, TE, Demons, JS, Sink, KM, Kennedy, K, Shertzer-Skinner, R, Wrights, A, Fries, R, Barr, D, Gill, TM, Axtell, RS, Kashaf, SS, de Rekeneire, N, McGloin, JM, Wu, KC, Shepard, DM, Fennelly, B, Iannone, LP, Mautner, R, Barnett, TS, Halpin, SN, Brennan, MJ, Bugaj, JA, Zenoni, MA, Mignosa, BM, Williamson, J, Sink, KM, Hendrie, HC, Rapp, SR, Verghese, J, Woolard, N, Espeland, M, Jennings, J, Wilson, VK, Pepine, CJ, Ariet, M, Handberg, E, Deluca, D, Hill, J, Szady, A, Chupp, GL, Flynn, GM, Gill, TM, Hankinson, JL, Vaz Fragoso, CA, Groessl, EJ & Kaplan, RM 2017, 'Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study', Journal of the American Medical Directors Association, vol. 18, no. 4, pp. 312-319. https://doi.org/10.1016/j.jamda.2016.10.001

Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older : The LIFE Study. / Aubertin-Leheudre, Mylène; Anton, Stephen; Beavers, Daniel P.; Manini, Todd M.; Fielding, Roger; Newman, Ann; Church, Tim; Kritchevsky, Stephen B.; Conroy, David; McDermott, Mary M.; Botoseneanu, Anda; Hauser, Michelle E.; Pahor, Marco; Gill, Thomas; Fragoso, Carlos; Fielding, Roger; Hauser, Michelle E.; Pahor, Marco; Guralnik, Jack M.; Leeuwenburgh, Christiaan; Caudle, Connie; Crump, Lauren; Holmes, Latonia; Lee, Jocelyn; Lu, Ching ju; Miller, Michael E.; Espeland, Mark A.; Ambrosius, Walter T.; Applegate, William; Beavers, Daniel P.; Byington, Robert P.; Cook, Delilah; Furberg, Curt D.; Harvin, Lea N.; Henkin, Leora; Hepler, Med John; Hsu, Fang Chi; Lovato, Laura; Roberson, Wesley; Rushing, Julia; Rushing, Scott; Stowe, Cynthia L.; Walkup, Michael P.; Hire, Don; Rejeski, W. Jack; Katula, Jeffrey A.; Brubaker, Peter H.; Mihalko, Shannon L.; Jennings, Janine M.; Hadley, Evan C.; Romashkan, Sergei; Patel, Kushang V.; Bonds, Denise; McDermott, Mary M.; Spring, Bonnie; Hauser, Joshua; Kerwin, Diana; Domanchuk, Kathryn; Graff, Rex; Rego, Alvito; Church, Timothy S.; Blair, Steven N.; Myers, Valerie H.; Monce, Ron; Britt, Nathan E.; Harris, Melissa Nauta; McGucken, Ami Parks; Rodarte, Ruben; Millet, Heidi K.; Tudor-Locke, Catrine; Butitta, Ben P.; Donatto, Sheletta G.; Cocreham, Shannon H.; King, Abby C.; Castro, Cynthia M.; Haskell, William L.; Stafford, Randall S.; Pruitt, Leslie A.; Berra, Kathy; Yank, Veronica; Fielding, Roger A.; Nelson, Miriam E.; Folta, Sara C.; Phillips, Edward M.; Liu, Christine K.; McDavitt, Erica C.; Reid, Kieran F.; Kirn, Dylan R.; Pasha, Evan P.; Kim, Won S.; Beard, Vince E.; Tsiroyannis, Eleni X.; Hau, Cynthia; Manini, Todd M.; Pahor, Marco; Anton, Stephen D.; Nayfield, Susan; Buford, Thomas W.; Marsiske, Michael; Sandesara, Bhanuprasad D.; Knaggs, Jeffrey D.; Lorow, Megan S.; Marena, William C.; Korytov, Irina; Morris, Holly L.; Fitch, Margo; Singletary, Floris F.; Causer, Jackie; Radcliff, Katie A.; Newman, Anne B.; Studenski, Stephanie A.; Goodpaster, Bret H.; Glynn, Nancy W.; Lopez, Oscar; Nadkarni, Neelesh K.; Williams, Kathy; Newman, Mark A.; Grove, George; Bonk, Janet T.; Rush, Jennifer; Kost, Piera; Ives, Diane G.; Kritchevsky, Stephen B.; Marsh, Anthony P.; Brinkley, Tina E.; Demons, Jamehl S.; Sink, Kaycee M.; Kennedy, Kimberly; Shertzer-Skinner, Rachel; Wrights, Abbie; Fries, Rose; Barr, Deborah; Gill, Thomas M.; Axtell, Robert S.; Kashaf, Susan S.; de Rekeneire, Nathalie; McGloin, Joanne M.; Wu, Karen C.; Shepard, Denise M.; Fennelly, Barbara; Iannone, Lynne P.; Mautner, Raeleen; Barnett, Theresa Sweeney; Halpin, Sean N.; Brennan, Matthew J.; Bugaj, Julie A.; Zenoni, Maria A.; Mignosa, Bridget M.; Williamson, Jeff; Sink, Kaycee M.; Hendrie, Hugh C.; Rapp, Stephen R.; Verghese, Joe; Woolard, Nancy; Espeland, Mark; Jennings, Janine; Wilson, Valerie K.; Pepine, Carl J.; Ariet, Mario; Handberg, Eileen; Deluca, Daniel; Hill, James; Szady, Anita; Chupp, Geoffrey L.; Flynn, Gail M.; Gill, Thomas M.; Hankinson, John L.; Vaz Fragoso, Carlos A.; Groessl, Erik J.; Kaplan, Robert M.

In: Journal of the American Medical Directors Association, Vol. 18, No. 4, 01.04.2017, p. 312-319.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older

T2 - The LIFE Study

AU - Aubertin-Leheudre, Mylène

AU - Anton, Stephen

AU - Beavers, Daniel P.

AU - Manini, Todd M.

AU - Fielding, Roger

AU - Newman, Ann

AU - Church, Tim

AU - Kritchevsky, Stephen B.

AU - Conroy, David

AU - McDermott, Mary M.

AU - Botoseneanu, Anda

AU - Hauser, Michelle E.

AU - Pahor, Marco

AU - Gill, Thomas

AU - Fragoso, Carlos

AU - Fielding, Roger

AU - Hauser, Michelle E.

AU - Pahor, Marco

AU - Guralnik, Jack M.

AU - Leeuwenburgh, Christiaan

AU - Caudle, Connie

AU - Crump, Lauren

AU - Holmes, Latonia

AU - Lee, Jocelyn

AU - Lu, Ching ju

AU - Miller, Michael E.

AU - Espeland, Mark A.

AU - Ambrosius, Walter T.

AU - Applegate, William

AU - Beavers, Daniel P.

AU - Byington, Robert P.

AU - Cook, Delilah

AU - Furberg, Curt D.

AU - Harvin, Lea N.

AU - Henkin, Leora

AU - Hepler, Med John

AU - Hsu, Fang Chi

AU - Lovato, Laura

AU - Roberson, Wesley

AU - Rushing, Julia

AU - Rushing, Scott

AU - Stowe, Cynthia L.

AU - Walkup, Michael P.

AU - Hire, Don

AU - Rejeski, W. Jack

AU - Katula, Jeffrey A.

AU - Brubaker, Peter H.

AU - Mihalko, Shannon L.

AU - Jennings, Janine M.

AU - Hadley, Evan C.

AU - Romashkan, Sergei

AU - Patel, Kushang V.

AU - Bonds, Denise

AU - McDermott, Mary M.

AU - Spring, Bonnie

AU - Hauser, Joshua

AU - Kerwin, Diana

AU - Domanchuk, Kathryn

AU - Graff, Rex

AU - Rego, Alvito

AU - Church, Timothy S.

AU - Blair, Steven N.

AU - Myers, Valerie H.

AU - Monce, Ron

AU - Britt, Nathan E.

AU - Harris, Melissa Nauta

AU - McGucken, Ami Parks

AU - Rodarte, Ruben

AU - Millet, Heidi K.

AU - Tudor-Locke, Catrine

AU - Butitta, Ben P.

AU - Donatto, Sheletta G.

AU - Cocreham, Shannon H.

AU - King, Abby C.

AU - Castro, Cynthia M.

AU - Haskell, William L.

AU - Stafford, Randall S.

AU - Pruitt, Leslie A.

AU - Berra, Kathy

AU - Yank, Veronica

AU - Fielding, Roger A.

AU - Nelson, Miriam E.

AU - Folta, Sara C.

AU - Phillips, Edward M.

AU - Liu, Christine K.

AU - McDavitt, Erica C.

AU - Reid, Kieran F.

AU - Kirn, Dylan R.

AU - Pasha, Evan P.

AU - Kim, Won S.

AU - Beard, Vince E.

AU - Tsiroyannis, Eleni X.

AU - Hau, Cynthia

AU - Manini, Todd M.

AU - Pahor, Marco

AU - Anton, Stephen D.

AU - Nayfield, Susan

AU - Buford, Thomas W.

AU - Marsiske, Michael

AU - Sandesara, Bhanuprasad D.

AU - Knaggs, Jeffrey D.

AU - Lorow, Megan S.

AU - Marena, William C.

AU - Korytov, Irina

AU - Morris, Holly L.

AU - Fitch, Margo

AU - Singletary, Floris F.

AU - Causer, Jackie

AU - Radcliff, Katie A.

AU - Newman, Anne B.

AU - Studenski, Stephanie A.

AU - Goodpaster, Bret H.

AU - Glynn, Nancy W.

AU - Lopez, Oscar

AU - Nadkarni, Neelesh K.

AU - Williams, Kathy

AU - Newman, Mark A.

AU - Grove, George

AU - Bonk, Janet T.

AU - Rush, Jennifer

AU - Kost, Piera

AU - Ives, Diane G.

AU - Kritchevsky, Stephen B.

AU - Marsh, Anthony P.

AU - Brinkley, Tina E.

AU - Demons, Jamehl S.

AU - Sink, Kaycee M.

AU - Kennedy, Kimberly

AU - Shertzer-Skinner, Rachel

AU - Wrights, Abbie

AU - Fries, Rose

AU - Barr, Deborah

AU - Gill, Thomas M.

AU - Axtell, Robert S.

AU - Kashaf, Susan S.

AU - de Rekeneire, Nathalie

AU - McGloin, Joanne M.

AU - Wu, Karen C.

AU - Shepard, Denise M.

AU - Fennelly, Barbara

AU - Iannone, Lynne P.

AU - Mautner, Raeleen

AU - Barnett, Theresa Sweeney

AU - Halpin, Sean N.

AU - Brennan, Matthew J.

AU - Bugaj, Julie A.

AU - Zenoni, Maria A.

AU - Mignosa, Bridget M.

AU - Williamson, Jeff

AU - Sink, Kaycee M.

AU - Hendrie, Hugh C.

AU - Rapp, Stephen R.

AU - Verghese, Joe

AU - Woolard, Nancy

AU - Espeland, Mark

AU - Jennings, Janine

AU - Wilson, Valerie K.

AU - Pepine, Carl J.

AU - Ariet, Mario

AU - Handberg, Eileen

AU - Deluca, Daniel

AU - Hill, James

AU - Szady, Anita

AU - Chupp, Geoffrey L.

AU - Flynn, Gail M.

AU - Gill, Thomas M.

AU - Hankinson, John L.

AU - Vaz Fragoso, Carlos A.

AU - Groessl, Erik J.

AU - Kaplan, Robert M.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.

AB - Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.

KW - Muscle strength

KW - aging

KW - metabolic syndrome

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85007449384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007449384&partnerID=8YFLogxK

U2 - 10.1016/j.jamda.2016.10.001

DO - 10.1016/j.jamda.2016.10.001

M3 - Article

VL - 18

SP - 312

EP - 319

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

SN - 1525-8610

IS - 4

ER -