Dynein: An Ancient Motor Protein Involved in Multiple Modes of Transport

Richard B. Vallee; John C. Williams; Dileep Varma; Lora E. Barnhart

doi:10.1002/neu.10314

Dynein: An Ancient Motor Protein Involved in Multiple Modes of Transport

Richard B. Vallee^*, John C. Williams, Dileep Varma, Lora E. Barnhart

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Review article › peer-review

365 Scopus citations

Abstract

Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed.

Original language	English (US)
Pages (from-to)	189-200
Number of pages	12
Journal	Journal of Neurobiology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1002/neu.10314
State	Published - Feb 5 2004

Keywords

AAA ATPase
Dynactin
Dynein
Microtubule
Motor protein
Neurofilament
Retrograde transport

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
General Neuroscience

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10.1002/neu.10314

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title = "Dynein: An Ancient Motor Protein Involved in Multiple Modes of Transport",

abstract = "Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed.",

keywords = "AAA ATPase, Dynactin, Dynein, Microtubule, Motor protein, Neurofilament, Retrograde transport",

author = "Vallee, {Richard B.} and Williams, {John C.} and Dileep Varma and Barnhart, {Lora E.}",

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T2 - An Ancient Motor Protein Involved in Multiple Modes of Transport

AU - Vallee, Richard B.

AU - Williams, John C.

AU - Varma, Dileep

AU - Barnhart, Lora E.

PY - 2004/2/5

Y1 - 2004/2/5

N2 - Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed.

AB - Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed.

KW - AAA ATPase

KW - Dynactin

KW - Dynein

KW - Microtubule

KW - Motor protein

KW - Neurofilament

KW - Retrograde transport

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DO - 10.1002/neu.10314

M3 - Review article

C2 - 14704951

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SN - 0022-3034

VL - 58

SP - 189

EP - 200

JO - Journal of Neurobiology

JF - Journal of Neurobiology

IS - 2

ER -

Dynein: An Ancient Motor Protein Involved in Multiple Modes of Transport

Abstract

Keywords

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