Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania

Catharina Armstrong*, Enju Liu, James Okuma, Donna Spiegelman, Chalamilla Guerino, Marina Njelekela, Steve Grinspoon, Wafaie Fawzi, Claudia Hawkins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume57
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • ART-naive
  • HIV positive
  • Tanzania
  • cardiovascular disease
  • dyslipidemia

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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