Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania

Catharina Armstrong; Enju Liu; James Okuma; Donna Spiegelman; Chalamilla Guerino; Marina Njelekela; Steve Grinspoon; Wafaie Fawzi; Claudia Hawkins

doi:10.1097/QAI.0b013e318219a3d1

Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania

Catharina Armstrong^*, Enju Liu, James Okuma, Donna Spiegelman, Chalamilla Guerino, Marina Njelekela, Steve Grinspoon, Wafaie Fawzi, Claudia Hawkins

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.

Original language	English (US)
Pages (from-to)	141-145
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	57
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e318219a3d1
State	Published - Jun 1 2011

Keywords

ART-naive
HIV positive
Tanzania
cardiovascular disease
dyslipidemia

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0b013e318219a3d1

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title = "Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania",

abstract = "Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.",

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AU - Armstrong, Catharina

AU - Liu, Enju

AU - Okuma, James

AU - Spiegelman, Donna

AU - Guerino, Chalamilla

AU - Njelekela, Marina

AU - Grinspoon, Steve

AU - Fawzi, Wafaie

AU - Hawkins, Claudia

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Y1 - 2011/6/1

N2 - Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.

AB - Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.

KW - ART-naive

KW - HIV positive

KW - Tanzania

KW - cardiovascular disease

KW - dyslipidemia

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Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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