Dyspepsia in childhood and adolescence: Insights and treatment considerations

Maria E. Perez, Nader N. Youssef*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Functional dyspepsia (FD) is common in children, with as many as 80% of those being evaluated for chronic abdominal pain reporting symptoms of epigastric discomfort, nausea, or fullness. It is known that patients with persistent complaints have increased comorbidities such as depression and anxiety. The interaction with psychopathologic variables has been found to mediate the association between upper abdominal pain and gastric hypersensitivity. These observations suggest that abnormal central nervous system processing of gastric stimuli may be a relevant pathophysiologic mechanism in FD. Despite increased understanding, no specific therapy has emerged; however, recent nonpharmacological-based options such as hypnosis may be effective. Novel approaches, including dietary manipulation and use of nutraceuticals such as ginger and Iberogast (Medical Futures Inc., Ontario, Canada), may also be considered.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalCurrent gastroenterology reports
Issue number6
StatePublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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