TY - JOUR
T1 - Dysregulation of Limbic and Auditory Networks in Tinnitus
AU - Leaver, Amber M.
AU - Renier, Laurent
AU - Chevillet, Mark A.
AU - Morgan, Susan
AU - Kim, Hung J.
AU - Rauschecker, Josef P.
N1 - Funding Information:
We wish to thank Jeremy Purcell, Kenta Takagaki, and Anne Fieger for their technical assistance. This work was funded by the National Institutes of Health (Grants RC1-DC010720 to J.P.R. and F31-DC008921 to A.M.L.), Skirball Foundation, Tinnitus Research Initiative, and Tinnitus Research Consortium.
PY - 2011/1/13
Y1 - 2011/1/13
N2 - Tinnitus is a common disorder characterized by ringing in the ear in the absence of sound. Converging evidence suggests that tinnitus pathophysiology involves damage to peripheral and/or central auditory pathways. However, whether auditory system dysfunction is sufficient to explain chronic tinnitus is unclear, especially in light of evidence implicating other networks, including the limbic system. Using functional magnetic resonance imaging and voxel-based morphometry, we assessed tinnitus-related functional and anatomical anomalies in auditory and limbic networks. Moderate hyperactivity was present in the primary and posterior auditory cortices of tinnitus patients. However, the nucleus accumbens exhibited the greatest degree of hyperactivity, specifically to sounds frequency-matched to patients' tinnitus. Complementary structural differences were identified in ventromedial prefrontal cortex, another limbic structure heavily connected to the nucleus accumbens. Furthermore, tinnitus-related anomalies were intercorrelated in the two limbic regions and between limbic and primary auditory areas, indicating the importance of auditory-limbic interactions in tinnitus.
AB - Tinnitus is a common disorder characterized by ringing in the ear in the absence of sound. Converging evidence suggests that tinnitus pathophysiology involves damage to peripheral and/or central auditory pathways. However, whether auditory system dysfunction is sufficient to explain chronic tinnitus is unclear, especially in light of evidence implicating other networks, including the limbic system. Using functional magnetic resonance imaging and voxel-based morphometry, we assessed tinnitus-related functional and anatomical anomalies in auditory and limbic networks. Moderate hyperactivity was present in the primary and posterior auditory cortices of tinnitus patients. However, the nucleus accumbens exhibited the greatest degree of hyperactivity, specifically to sounds frequency-matched to patients' tinnitus. Complementary structural differences were identified in ventromedial prefrontal cortex, another limbic structure heavily connected to the nucleus accumbens. Furthermore, tinnitus-related anomalies were intercorrelated in the two limbic regions and between limbic and primary auditory areas, indicating the importance of auditory-limbic interactions in tinnitus.
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U2 - 10.1016/j.neuron.2010.12.002
DO - 10.1016/j.neuron.2010.12.002
M3 - Article
C2 - 21220097
AN - SCOPUS:78650946816
VL - 69
SP - 33
EP - 43
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -