Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification

Lixin Kan*, Yijie Liu, Tammy L. McGuire, Diana M. Palila Berger, Rajeshwar B. Awatramani, Susan M. Dymecki, John A. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalStem Cells
Volume27
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Fibrodysplasia ossificans progressiva
  • Heterotopic ossification
  • Macrophages
  • Nse-BMP4

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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