Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification

Lixin Kan; Yijie Liu; Tammy L. McGuire; Diana M. Palila Berger; Rajeshwar B. Awatramani; Susan M. Dymecki; John A. Kessler

doi:10.1634/stemcells.2008-0576

Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification

Lixin Kan^*, Yijie Liu, Tammy L. McGuire, Diana M. Palila Berger, Rajeshwar B. Awatramani, Susan M. Dymecki, John A. Kessler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.

Original language	English (US)
Pages (from-to)	150-156
Number of pages	7
Journal	Stem Cells
Volume	27
Issue number	1
DOIs	https://doi.org/10.1634/stemcells.2008-0576
State	Published - Jan 2009

Keywords

Fibrodysplasia ossificans progressiva
Heterotopic ossification
Macrophages
Nse-BMP4

ASJC Scopus subject areas

Medicine(all)

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title = "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification",

abstract = "Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.",

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AU - Palila Berger, Diana M.

AU - Awatramani, Rajeshwar B.

AU - Dymecki, Susan M.

AU - Kessler, John A.

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AB - Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.

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Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification

Abstract

Keywords

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