Early changes in tumor metabolism after treatment: The effects of stereotactic radiotherapy

Jack M. Rozental*, Ross L. Levine, Minesh P. Mehta, Timothy J. Kinsella, Allan B. Levin, Ozer Allan, Manuel Mendoza, Joan M. Hanson, Debra A. Schrader, Robert J. Nickles

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Four patients with intracranial neoplasms, two with malignant gliomas and two with brain metastases, were treated with stereotactic radiotherapy. Patients received between 15 and 27.5 Gray of photon irradiation to the central tumor target point; the 80% isodose line covered the periphery of the tumor as determined by contrast enhanced computed tomography. Patients underwent a sequence of three Positron Emission Tomographic scans using [18F]-fluorodeoxyglucose (PET-FDG)-a baseline scan the day before treatment, and follow-up scans 1 and 7 days after treatment. Ratios between the maximal tumor regional cerebral metabolic rate for glucose (rCMRGlu) (T*) and the contralateral remote white matter rCMRGlu (RW), that is, the glucose uptake ratio (T*/RW), were calculated. The percent change in ratios relative to each patient's baseline scan were calculated. Ratios increased 25% to 42% 1 day post-radiotherapy, then decreased to between 10% above and 12% below the baseline value 7 days postradiotherapy. The T*/RW increased acutely after stereotactic radiotherapy in a fashion similar to that previously described following chemotherapy with a complex multi-drug regimen. A common metabolic pathway may underlie the increase in T*/RW after these different treatments.

Original languageEnglish (US)
Pages (from-to)1053-1060
Number of pages8
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume20
Issue number5
DOIs
StatePublished - May 1 1991

Keywords

  • Brain tumor
  • Glioma metabolism
  • PET
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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