Early detection and personalized medicine: Future strategies against Alzheimer's disease

Antonio Di Meco*, Robert Vassar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Alzheimer's disease (AD) is the leading cause of dementia and sixth cause of death in elderly adults. AD poses a huge economic burden on society and constitutes an unprecedented challenge for caregivers and families affected. Aging of the population is projected to drastically aggravate the situation in the near future. To date, no therapy is available to prevent or ameliorate the disease. Moreover, several clinical trials for promising therapeutic agents have failed. Lack of supporting biomarker data for pre-symptomatic enrollment and inaccurate stratification of patients based on genetic heterogeneity appear to be contributing factors to this lack of success. Recently, the treatment of cancer has seen enormous advances based on the personalized genetics and biomarkers of the individual patient, forming the foundation of precision medicine for cancer. Likewise, technological progress in AD biomarker research promises the availability of reliable assays for pathology staging on a routine basis relatively soon. Moreover, tremendous achievements in AD genetics and high-throughput genotyping technology allow identification of predisposing risk alleles accurately and on a large scale. Finally, availability of electronic health records (EHR) promises the opportunity to integrate biomarker, genomic and clinical data efficiently. Together, these advances will form the basis of precision medicine for AD.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsDavid B. Teplow
PublisherElsevier B.V.
Pages157-173
Number of pages17
ISBN (Print)9780128241431
DOIs
StatePublished - Jan 2021

Publication series

NameProgress in Molecular Biology and Translational Science
Volume177
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Future strategy
  • Genetic testing
  • Personalized medicine
  • Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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