TY - JOUR
T1 - Early diagnosis of HIV infection in infants
AU - Albert, Jan
AU - Biberfeld, Gunnell
AU - Borkowsky, William
AU - Caniglia, Maurizio
AU - De, Anita Rossi
AU - Elia, Luigi
AU - Fundaro, Carlo
AU - Giaquinto, Carlo
AU - Henrard, Denis
AU - Hoff, Rodney
AU - Jansson, Marianne
AU - Lombardi, Valter
AU - Marchisio, Paola
AU - Pahwa, Savita
AU - Plebani, Anna
AU - Rogers, Martha
AU - Rossi, Paolo
AU - Rouzioux, Christine
AU - Scarlatti, Gabriella
AU - Scott, Gwendolyn
AU - Tamashiro, Hiko
AU - van, Guido der Groen
AU - Verani, Paola
AU - Wahren, Britta
AU - Wolinsky, Steven
AU - Consensus Workshop
PY - 1992/11
Y1 - 1992/11
N2 - To promote progress in the research and development of early diagnostic tests for HIV in young children an international workshop was held on January 17-18, 1992, in Siena, Italy. Experts on pediatric AIDS, diagnostic retro virology, and immunodiagnosis discussed and summarized the state-of-the-art and made recommendations for general application of several tests and further evaluation and continued research for other candidate tests. From the discussions it was clear that the field has advanced beyond the time when it was necessary to wait until the infant reached 18 months of age before attempting the diagnosis with conventional serologic tests for HIV. About half of infected infants can now be identified at birth, ˜90% by 3 months of age, and almost all by 6 months of age using HIV culture and polymerase chain reaction assays. IgA antibody tests and p24 antigen tests have also proved useful, although they are not as sensitive in newborn infants. The fact that HIV can be detected in only one-half of infected infants at the time of birth points to the need for further research on the timing of transmission and the natural history of perinatally acquired HIV infection to understand the limitations of current early diagnostic tests and to develop new approaches to overcome these problems.
AB - To promote progress in the research and development of early diagnostic tests for HIV in young children an international workshop was held on January 17-18, 1992, in Siena, Italy. Experts on pediatric AIDS, diagnostic retro virology, and immunodiagnosis discussed and summarized the state-of-the-art and made recommendations for general application of several tests and further evaluation and continued research for other candidate tests. From the discussions it was clear that the field has advanced beyond the time when it was necessary to wait until the infant reached 18 months of age before attempting the diagnosis with conventional serologic tests for HIV. About half of infected infants can now be identified at birth, ˜90% by 3 months of age, and almost all by 6 months of age using HIV culture and polymerase chain reaction assays. IgA antibody tests and p24 antigen tests have also proved useful, although they are not as sensitive in newborn infants. The fact that HIV can be detected in only one-half of infected infants at the time of birth points to the need for further research on the timing of transmission and the natural history of perinatally acquired HIV infection to understand the limitations of current early diagnostic tests and to develop new approaches to overcome these problems.
KW - Early diagnosis in infants
KW - HIV ELISPOT test
KW - HIV IgA test
KW - HIV culture
KW - HIV in vitro antibody production test
KW - HIV p24 test
KW - HIV polymerase chain reaction test
KW - Pediatrie HIV-1 infection
UR - http://www.scopus.com/inward/record.url?scp=84938475604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938475604&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84938475604
SN - 1525-4135
VL - 5
SP - 1169
EP - 1178
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 11
ER -
