Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved

Christopher Hine; Derek A. Wainwright; Justin D. Lathia

doi:10.1016/j.chembiol.2021.11.007

Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H₂S production: A paradox resolved

Christopher Hine^*, Derek A. Wainwright, Justin D. Lathia

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H₂S generation initiated by DNA damage and other small molecule treatments.

Original language	English (US)
Pages (from-to)	1665-1668
Number of pages	4
Journal	Cell Chemical Biology
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.chembiol.2021.11.007
State	Published - Dec 16 2021

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2021.11.007

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abstract = "Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments.",

author = "Christopher Hine and Wainwright, {Derek A.} and Lathia, {Justin D.}",

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AB - Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments.

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Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H₂S production: A paradox resolved

Abstract

ASJC Scopus subject areas

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