Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved

Christopher Hine*, Derek A. Wainwright, Justin D. Lathia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments.

Original languageEnglish (US)
Pages (from-to)1665-1668
Number of pages4
JournalCell Chemical Biology
Volume28
Issue number12
DOIs
StatePublished - Dec 16 2021

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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