Early drug distribution: A generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents

T. K. Henthorn, T. C. Krejcie, M. J. Avram

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

There is considerable variability in response to intravenously administered anesthetic drugs (e.g., hypnotics, benzodiazepines, and narcotics) that have a rapid onset of effect (such as hypnosis, anxiolysis, and analgesia) and a low margin of safety (because of cardiovascular or respiratory depression, etc.). Although the onset of effect for these drugs occurs seconds to minutes after injection, traditional pharmacokinetic models are based on blood samples that are first obtained after drug effects have peaked. As a result, many studies have failed to provide a pharmacokinetic rationale for dosage adjustments of these drugs.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalClinical pharmacology and therapeutics
Volume84
Issue number1
DOIs
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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